MMP1 and CCL13

Number of citations of the paper that reports this interaction (PMID 12149192)
92

Data Source:
HPRD (in vitro, in vivo)

		MMP1	CCL13
Gene Name		matrix metallopeptidase 1 (interstitial collagenase)	chemokine (C-C motif) ligand 13
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix	Extracellular Space
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding	Receptor Binding Chemokine Activity
	Biological Process	Proteolysis Blood Coagulation Viral Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Protein Metabolic Process Leukocyte Migration	Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Eosinophil Chemotaxis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Basigin interactions Cell surface interactions at the vascular wall
Drugs		Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N\'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases
GWAS			Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		17 interactors: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	8 interactors: ACKR2 ACKR4 APP CCR3 CCR5 HNRNPH3 MMP1 MMP3
Entrez ID		4312	6357
HPRD ID		00384	03230
Ensembl ID		ENSG00000196611	ENSG00000181374
Uniprot IDs		B4DN15 P03956 Q53G95	Q99616
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C	2RA4
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Locomotion Cell Motility Monocyte Chemotaxis Organ Morphogenesis Movement Of Cell Or Subcellular Component Leukocyte Chemotaxis Chemotaxis Response To Stress Cell Chemotaxis Regulation Of Protein Metabolic Process Response To Wounding Organ Development Glycosaminoglycan Catabolic Process Blood Coagulation Inflammatory Response Hemostasis Granulocyte Chemotaxis Eosinophil Chemotaxis Response To Organic Substance Eosinophil Migration Connective Tissue Development Homeostatic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Positive Regulation Of Leukocyte Migration Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Developmental Process Ossification Regulation Of Cell Migration Wound Healing Proteoglycan Metabolic Process Calcium Ion Homeostasis Regulation Of Cell Motility Positive Regulation Of Chemotaxis Response To Stimulus Regulation Of Leukocyte Migration Regulation Of Locomotion Negative Regulation Of Proteolysis Regulation Of Cellular Component Movement Positive Regulation Of Behavior Regulation Of Catalytic Activity Tissue Development Negative Regulation Of Protein Processing Anatomical Structure Morphogenesis	Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Oligomerization Cellular Response To Cytokine Stimulus Regulation Of Protein Oligomerization Response To Cytokine Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To External Stimulus Cellular Response To Organic Substance Cellular Defense Response Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Response To Stress Cellular Metal Ion Homeostasis Immune System Process Inflammatory Response Collagen Metabolic Process G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Multicellular Organismal Macromolecule Metabolic Process Cellular Ion Homeostasis Multicellular Organismal Metabolic Process Metal Ion Homeostasis Extracellular Matrix Disassembly Immune Response Response To Organic Substance Cellular Chemical Homeostasis Defense Response Viral Process Synaptic Growth At Neuromuscular Junction Ion Homeostasis Collateral Sprouting In Absence Of Injury Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Surface Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Cytosolic Calcium Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	3b amylin bead bmi ccl19 ccl2 correction cxcl10 cxcl12 cxcl5 cxcl6 draw ena epidemiologic examining fdr gcp2 inactivity mcp mip multiplex nested obesity ors sdf stnfrii topic twelve vigorous
Tagcloud (Difference) ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	3b amylin bead bmi ccl19 ccl2 correction cxcl10 cxcl12 cxcl5 cxcl6 draw ena epidemiologic examining fdr gcp2 inactivity mcp mip multiplex nested obesity ors sdf stnfrii topic twelve vigorous
Tagcloud (Intersection) ?