MMP1

Gene Name		matrix metallopeptidase 1 (interstitial collagenase)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Proteolysis Blood Coagulation Viral Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Basigin interactions Cell surface interactions at the vascular wall
Drugs		Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N\'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases
GWAS
Protein-protein Interactions		17 interactors: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11
Entrez ID		4312
HPRD ID		00384
Ensembl ID		ENSG00000196611
Uniprot IDs		B4DN15 P03956 Q53G95
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Locomotion Cell Motility Monocyte Chemotaxis Organ Morphogenesis Movement Of Cell Or Subcellular Component Leukocyte Chemotaxis Chemotaxis Response To Stress Cell Chemotaxis Regulation Of Protein Metabolic Process Response To Wounding Organ Development Glycosaminoglycan Catabolic Process Blood Coagulation Inflammatory Response Hemostasis Granulocyte Chemotaxis Eosinophil Chemotaxis Response To Organic Substance Eosinophil Migration Connective Tissue Development Homeostatic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Positive Regulation Of Leukocyte Migration Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Developmental Process Ossification Regulation Of Cell Migration Wound Healing Proteoglycan Metabolic Process Calcium Ion Homeostasis Regulation Of Cell Motility Positive Regulation Of Chemotaxis Response To Stimulus Regulation Of Leukocyte Migration Regulation Of Locomotion Negative Regulation Of Proteolysis Regulation Of Cellular Component Movement Positive Regulation Of Behavior Regulation Of Catalytic Activity Tissue Development Negative Regulation Of Protein Processing Anatomical Structure Morphogenesis
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2