PEX16 and PEX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		PEX16	PEX3
Description		peroxisomal biogenesis factor 16	peroxisomal biogenesis factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Nucleoplasm Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Protein-containing Complex Protein-lipid Complex
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Matrix Protein To Membrane Docking ER-dependent Peroxisome Organization Protein Import Into Peroxisome Membrane ER-dependent Peroxisome Localization	Peroxisome Organization Protein Import Into Peroxisome Membrane
Pathways		Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) SAPHO syndrome ( 33816493)	Skin aging measurement ( 31522824)
Interacting Genes		35 interacting genes: AQP6 BDKRB2 BIK CD79A CLEC10A CREB3L1 CYB5R3 DEXI EBAG9 ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FKBP7 GPR152 KCNJ6 LEPROTL1 MMGT1 PDZK1IP1 PEX19 PEX3 PGRMC2 REEP4 SAR1A SLC10A1 SLC10A6 SLC18A1 SLC35H1 SLC71A2 TIMMDC1 TMX2 TNFRSF17 UBC ZDHHC15	2 interacting genes: PEX16 PEX19
Entrez ID		9409	8504
HPRD ID		04526	04407
Ensembl ID		ENSG00000121680	ENSG00000034693
Uniprot IDs		E9PP98 Q9Y5Y5	P56589
PDB IDs			3AJB 3MK4
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Protein Import Into Peroxisome Membrane Protein Binding Serotonin Transport Adaptive Immune Response Organic Hydroxy Compound Transport Mitochondrial Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Bile Acid And Bile Salt Transport	Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Membrane Membrane Biogenesis Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Brush Border Membrane Peroxisomal Membrane Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization Peroxisome Peroxisome Membrane Targeting Sequence Binding Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Protein Targeting Establishment Of Protein Localization To Membrane Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Synaptic Receptor Adaptor Activity Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Protein To Membrane Docking S-shaped Body Morphogenesis Regulation Of Female Gonad Development Metanephric Mesenchyme Development Protein Localization To Membrane Diaphragm Development Positive Regulation Of Male Gonad Development Cardiac Muscle Cell Fate Commitment Establishment Of Protein Localization To Organelle Protein Carrier Chaperone Peroxisome Fission Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Neurofilament Podocyte Differentiation Nephron Tubule Morphogenesis Muscle Cell Fate Commitment C2H2 Zinc Finger Domain Binding Protein Import Into Peroxisome Matrix Metanephric Epithelium Development
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