PEX16 and TNFRSF17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PEX16	TNFRSF17
Description		peroxisomal biogenesis factor 16	TNF receptor superfamily member 17
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Plasma Membrane Endomembrane System Membrane
	Molecular Function	Protein Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Matrix Protein To Membrane Docking ER-dependent Peroxisome Organization Protein Import Into Peroxisome Membrane ER-dependent Peroxisome Localization	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	TNFs bind their physiological receptors
Drugs			Belantamab mafodotin Teclistamab Idecabtagene vicleucel Ciltacabtagene autoleucel
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) SAPHO syndrome ( 33816493)	Blood protein levels ( 30072576) Phenylephrine infusion rate during anesthesia ( 31455332) QT interval ( 19305408) Testicular germ cell tumor ( 26503584)
Interacting Genes		35 interacting genes: AQP6 BDKRB2 BIK CD79A CLEC10A CREB3L1 CYB5R3 DEXI EBAG9 ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FKBP7 GPR152 KCNJ6 LEPROTL1 MMGT1 PDZK1IP1 PEX19 PEX3 PGRMC2 REEP4 SAR1A SLC10A1 SLC10A6 SLC18A1 SLC35H1 SLC71A2 TIMMDC1 TMX2 TNFRSF17 UBC ZDHHC15	8 interacting genes: CMTM7 PEX16 TMBIM6 TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3
Entrez ID		9409	608
HPRD ID		04526	00144
Ensembl ID		ENSG00000121680	ENSG00000048462
Uniprot IDs		E9PP98 Q9Y5Y5	Q02223
PDB IDs			1OQD 1XU2 2KN1 4ZFO 6J7W 8HXQ 8HXR 8QY9 8QYA 8QYB
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Protein Import Into Peroxisome Membrane Protein Binding Serotonin Transport Adaptive Immune Response Organic Hydroxy Compound Transport Mitochondrial Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Bile Acid And Bile Salt Transport	Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding Regulation Of Immunoglobulin Production Signaling Adaptor Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Cytokine-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of DNA-binding Transcription Factor Activity Regulation Of Production Of Molecular Mediator Of Immune Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Cytokine Activity Positive Regulation Of Immune Response Positive Regulation Of B Cell Proliferation Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction TORC2 Complex Disassembly Regulation Of B Cell Proliferation Lymphocyte Homeostasis ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization ABC-type Vitamin B12 Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Sphingolipid Transporter Activity Cell Death Apoptotic Process Endoribonuclease Inhibitor Activity Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune Response Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Leukocyte Homeostasis Positive Regulation Of B Cell Activation Positive Regulation Of Germinal Center Formation Transitional One Stage B Cell Differentiation B-1a B Cell Differentiation Positive Regulation Of Immune System Process Signal Transduction Immune System Process Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex
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