TMEM14B and PDPN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM14B	PDPN
Description		transmembrane protein 14B	podoplanin
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Mitochondrial Membrane	Ruffle Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Cell Junction Filopodium Lamellipodium Membrane Cytoplasmic Vesicle Filopodium Membrane Microvillus Membrane Ruffle Membrane Cell Projection Membrane Raft Leading Edge Of Lamellipodium Anchoring Junction Tetraspanin-enriched Microdomain
	Molecular Function	Protein Binding Identical Protein Binding	Signaling Receptor Binding Water Transmembrane Transporter Activity Protein Binding Folic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Water Channel Activity Chemokine Binding Protein-folding Chaperone Binding
	Biological Process	Heme Biosynthetic Process Nervous System Development Cerebral Cortex Development Neural Precursor Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Lymphangiogenesis Water Transport Amino Acid Transport Cell Adhesion Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Folic Acid Transport Cell Migration Platelet Activation Lung Development Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Process Wound Healing, Spreading Of Cells Lymph Node Development Lymphatic Endothelial Cell Fate Commitment Actin-mediated Cell Contraction Positive Regulation Of Extracellular Matrix Disassembly Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Regulation Of Myofibroblast Contraction Regulation Of Lamellipodium Morphogenesis
Pathways			GPVI-mediated activation cascade Specification of primordial germ cells
Drugs
Diseases
GWAS		Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		235 interacting genes: ABHD16A ABHD5 ACSL5 ADAM33 AGPAT3 AGPAT4 AGR3 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARL8B ARV1 ATP13A1 B4GALT7 BIK BLCAP BMP10 BSG BTN2A2 C10orf67 C14orf180 C1GALT1 C2CD2L CCL4 CD79A CEPT1 CFHR5 CIDEB CLDN10 CLDND2 CMTM5 CMTM8 CNIH2 CNIH3 CNIH4 COMT CPLX4 CREB3 CREB3L1 CXCL16 CYB561 CYB5R3 DEFB103A DEFB103B DGAT2L6 DHRSX EBP EI24 EMC6 EPHX4 ERGIC3 EXTL1 FA2H FADS6 FAM209A FCER1G FHL3 FIS1 FKBP8 FUNDC2 FXYD6-FXYD2 GDAP1 GIMAP1 GPR152 GPX8 GYPA GYPC HEXB HIBADH HIGD1C HMOX1 HMOX2 HSD17B11 HSD17B13 HSD3B1 IER3IP1 IFITM3 INSIG2 ITGAM JAGN1 KCNA1 KCNK1 KHDRBS2 LEPROTL1 LMNA LPAR3 LRCH1 MAL2 MARCHF5 MEOX2 MFSD12 MGAM MID2 MMD2 MS4A13 MS4A4A NAT8 NCALD NDUFA3 NEU1 NINJ1 NINJ2 NIPAL3 ORMDL1 OTULINL PAGE1 PDPN PDZK1IP1 PEX11G PIGF PLLP PLP1 PLP2 PMP22 PNLIPRP1 PPP2R3B PRAF2 PRH1 PRTFDC1 PSMD3 PTPMT1 RABAC1 REEP4 RHD RHOT2 SAR1B SCAMP5 SCN3B SCRG1 SERF1A SERF1B SERP1 SERP2 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SLC10A6 SLC16A10 SLC16A13 SLC18A1 SLC19A3 SLC2A6 SLC30A3 SLC30A8 SLC35A4 SLC35E3 SLC35E4 SLC35F1 SLC35F6 SLC35G1 SLC35H1 SLC39A2 SLC39A7 SLC48A1 SLC61A1 SLC7A8 SMAGP SMPD2 SPRY2 SQLE ST6GAL2 STOM STX12 STX3 STX6 STX8 SUCNR1 SYNGR1 SYNJ2BP TAP1 TAS2R19 TBC1D20 TEX44 THBD TIMM22 TIMM23 TIMMDC1 TLCD1 TM4SF4 TMEM11 TMEM120A TMEM120B TMEM121 TMEM147 TMEM14A TMEM14C TMEM187 TMEM19 TMEM203 TMEM220 TMEM222 TMEM229B TMEM243 TMEM254 TMEM255B TMEM267 TMEM42 TMEM50A TMEM50B TMEM51 TMEM60 TMEM69 TMEM97 TMIE TMUB1 TMX2 TOMM6 TSPAN2 TSPO TVP23B UBE2J1 UBE2J2 UBE3A UBIAD1 UBXN8 UNC50 UNC93A VAMP1 VAMP5 VMA12 VRK2 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC11 ZDHHC22 ZDHHC24 ZFPL1	2 interacting genes: TMEM14B TOM1L1
Entrez ID		81853	10630
HPRD ID		15523	16398
Ensembl ID		ENSG00000137210	ENSG00000162493
Uniprot IDs		A0A087WU83 C9JCY4 C9JQS0 Q9NUH8	Q86YL7
PDB IDs			3WSR 4YO0 5XCV 7C94 7CQC 7CQD
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Endomembrane System Golgi Apparatus Lipid Biosynthetic Process Membrane Organization Cellular Localization Transmembrane Transport Golgi Membrane Mitochondrial Outer Membrane Transmembrane Transporter Activity Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Establishment Of Protein Localization Serine Import Into Mitochondrion Organic Cation Transport SNARE Complex Structural Constituent Of Myelin Sheath Mitochondrial Membrane SNAP Receptor Activity Organelle Fusion Monoatomic Ion Transmembrane Transporter Activity Steroid Biosynthetic Process Amino Acid Transport Myelination Axon Ensheathment Vesicle Fusion Organic Hydroxy Compound Transport Organelle Membrane Fusion Lipid Homeostasis Heme Metabolic Process Pigment Metabolic Process Cholesterol Biosynthetic Process Golgi Trans Cisterna Import Into The Mitochondrion COPII-coated ER To Golgi Transport Vesicle Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Amino Acid Transmembrane Transport Golgi Medial Cisterna SNARE Binding Zinc Ion Transmembrane Transporter Activity Sterol Biosynthetic Process Serine Transport Porphyrin-containing Compound Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Chemical Homeostasis	Sequence-specific DNA Binding Histone Methyltransferase Activity GATOR1 Complex Binding Cervix Development Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Metanephric Comma-shaped Body Morphogenesis Uterine Epithelium Development Positive Regulation Of Anterior Head Development Dorsal Spinal Cord Interneuron Posterior Axon Guidance Nephric Duct Elongation Ectoderm Formation Metanephric Glomerulus Development Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Spinal Cord Interneuron Axon Guidance DNA-binding Transcription Factor Activity Regulation Of Hemoglobin Biosynthetic Process Protein-arginine Omega-N Monomethyltransferase Activity N-methyltransferase Activity Mitogen-activated Protein Kinase P38 Binding Response To Methionine Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Methyltransferase Activity Cellular Response To Methionine Methylation Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Metanephric Part Of Ureteric Bud Development Pronephros Development Interneuron Axon Guidance Mesendoderm Development Oviduct Development Positive Regulation Of Gastrulation Lateral Motor Column Neuron Migration Oviduct Epithelium Development Anterior/posterior Axon Guidance Embryonic Retina Morphogenesis In Camera-type Eye Ureter Morphogenesis Spinal Cord Motor Neuron Migration S-shaped Body Morphogenesis Nephric Duct Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Comma-shaped Body Morphogenesis Mesonephric Duct Development Forebrain Regionalization Paramesonephric Duct Development Metanephric S-shaped Body Morphogenesis Histone H3K9 Trimethyltransferase Activity
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