TMEM14B and CPLX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM14B	CPLX4
Description		transmembrane protein 14B	complexin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane Mitochondrial Membrane	Plasma Membrane Membrane SNARE Complex Terminal Bouton Synapse
	Molecular Function	Protein Binding Identical Protein Binding	SNARE Binding Protein Binding Syntaxin Binding
	Biological Process	Heme Biosynthetic Process Nervous System Development Cerebral Cortex Development Neural Precursor Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Neurotransmitter Transport Exocytosis Visual Perception Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)	Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321)
Interacting Genes		235 interacting genes: ABHD16A ABHD5 ACSL5 ADAM33 AGPAT3 AGPAT4 AGR3 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARL8B ARV1 ATP13A1 B4GALT7 BIK BLCAP BMP10 BSG BTN2A2 C10orf67 C14orf180 C1GALT1 C2CD2L CCL4 CD79A CEPT1 CFHR5 CIDEB CLDN10 CLDND2 CMTM5 CMTM8 CNIH2 CNIH3 CNIH4 COMT CPLX4 CREB3 CREB3L1 CXCL16 CYB561 CYB5R3 DEFB103A DEFB103B DGAT2L6 DHRSX EBP EI24 EMC6 EPHX4 ERGIC3 EXTL1 FA2H FADS6 FAM209A FCER1G FHL3 FIS1 FKBP8 FUNDC2 FXYD6-FXYD2 GDAP1 GIMAP1 GPR152 GPX8 GYPA GYPC HEXB HIBADH HIGD1C HMOX1 HMOX2 HSD17B11 HSD17B13 HSD3B1 IER3IP1 IFITM3 INSIG2 ITGAM JAGN1 KCNA1 KCNK1 KHDRBS2 LEPROTL1 LMNA LPAR3 LRCH1 MAL2 MARCHF5 MEOX2 MFSD12 MGAM MID2 MMD2 MS4A13 MS4A4A NAT8 NCALD NDUFA3 NEU1 NINJ1 NINJ2 NIPAL3 ORMDL1 OTULINL PAGE1 PDPN PDZK1IP1 PEX11G PIGF PLLP PLP1 PLP2 PMP22 PNLIPRP1 PPP2R3B PRAF2 PRH1 PRTFDC1 PSMD3 PTPMT1 RABAC1 REEP4 RHD RHOT2 SAR1B SCAMP5 SCN3B SCRG1 SERF1A SERF1B SERP1 SERP2 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SLC10A6 SLC16A10 SLC16A13 SLC18A1 SLC19A3 SLC2A6 SLC30A3 SLC30A8 SLC35A4 SLC35E3 SLC35E4 SLC35F1 SLC35F6 SLC35G1 SLC35H1 SLC39A2 SLC39A7 SLC48A1 SLC61A1 SLC7A8 SMAGP SMPD2 SPRY2 SQLE ST6GAL2 STOM STX12 STX3 STX6 STX8 SUCNR1 SYNGR1 SYNJ2BP TAP1 TAS2R19 TBC1D20 TEX44 THBD TIMM22 TIMM23 TIMMDC1 TLCD1 TM4SF4 TMEM11 TMEM120A TMEM120B TMEM121 TMEM147 TMEM14A TMEM14C TMEM187 TMEM19 TMEM203 TMEM220 TMEM222 TMEM229B TMEM243 TMEM254 TMEM255B TMEM267 TMEM42 TMEM50A TMEM50B TMEM51 TMEM60 TMEM69 TMEM97 TMIE TMUB1 TMX2 TOMM6 TSPAN2 TSPO TVP23B UBE2J1 UBE2J2 UBE3A UBIAD1 UBXN8 UNC50 UNC93A VAMP1 VAMP5 VMA12 VRK2 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC11 ZDHHC22 ZDHHC24 ZFPL1	100 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 APOD AQP1 AQP9 ASGR1 ATP6V0C BMP10 BNIP2 C14orf180 C1GALT1 C3orf52 C5 CACNG1 CCL4L2 CD81 CDIPT CDS2 CLDND2 CLEC4G CLN6 CMTM5 CNIH1 CTSA CTXN3 CYB5B CYBC1 CYP4F2 DEFB127 EMD GAD2 GIMAP1 GRM2 HACD1 HHATL HMOX1 IGFBP5 INSIG2 LHFPL5 LPAR3 MAL MALL MAN2B2 MGAM NINJ2 NRM ORMDL1 PGAP2 PLN PLP2 PLPP4 PNLIPRP1 PTPN9 RTP2 SEC22B SELENOK SFTPC SLC30A2 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC38A7 SLC39A9 SMCO4 SMIM1 SNCA STX3 STX8 SYNJ2BP TF TMEM107 TMEM120B TMEM128 TMEM14A TMEM14B TMEM19 TMEM201 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM267 TMEM42 TMEM60 TMEM79 TMEM86A TMEM97 TRAF3IP3 TSPO2 UBIAD1 VAMP4 VAMP5 VKORC1 WFDC2 YIPF6 ZFPL1
Entrez ID		81853	339302
HPRD ID		15523	13091
Ensembl ID		ENSG00000137210	ENSG00000166569
Uniprot IDs		A0A087WU83 C9JCY4 C9JQS0 Q9NUH8	Q7Z7G2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Endomembrane System Golgi Apparatus Lipid Biosynthetic Process Membrane Organization Cellular Localization Transmembrane Transport Golgi Membrane Mitochondrial Outer Membrane Transmembrane Transporter Activity Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Establishment Of Protein Localization Serine Import Into Mitochondrion Organic Cation Transport SNARE Complex Structural Constituent Of Myelin Sheath Mitochondrial Membrane SNAP Receptor Activity Organelle Fusion Monoatomic Ion Transmembrane Transporter Activity Steroid Biosynthetic Process Amino Acid Transport Myelination Axon Ensheathment Vesicle Fusion Organic Hydroxy Compound Transport Organelle Membrane Fusion Lipid Homeostasis Heme Metabolic Process Pigment Metabolic Process Cholesterol Biosynthetic Process Golgi Trans Cisterna Import Into The Mitochondrion COPII-coated ER To Golgi Transport Vesicle Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Amino Acid Transmembrane Transport Golgi Medial Cisterna SNARE Binding Zinc Ion Transmembrane Transporter Activity Sterol Biosynthetic Process Serine Transport Porphyrin-containing Compound Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Chemical Homeostasis	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Golgi Membrane Cholesterol Binding Intracellular Chemical Homeostasis Monoatomic Cation Homeostasis Pyrimidine Nucleotide-sugar Transmembrane Transport Monoatomic Ion Homeostasis Nucleotide-sugar Transmembrane Transport Homeostatic Process Vitamin K Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Golgi Apparatus Spindle Pole Centrosome Cellular Homeostasis Hydrogen Peroxide Channel Activity Negative Regulation Of Chaperone-mediated Autophagy Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Hydrogen Peroxide Transmembrane Transport Nuclear Inner Membrane Respiratory Burst After Phagocytosis Regulation Of Chemokine Production Negative Regulation Of Lipoprotein Metabolic Process Cellular Response To CAMP Zinc:proton Antiporter Activity Zinc Ion Transmembrane Transporter Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Zinc Ion Transmembrane Transport Menaquinone Metabolic Process Lysosome Zinc Ion Transport Glycerol Transmembrane Transport Multicellular Organismal-level Chemical Homeostasis Intracellular Zinc Ion Homeostasis Positive Regulation Of Chemokine Production Cortical Endoplasmic Reticulum Regulation Of Chaperone-mediated Autophagy Endomembrane System Long-chain Fatty Acid Catabolic Process Regulation Of Cellular Localization
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