TMEM14B and FHL3

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		TMEM14B	FHL3
Description		transmembrane protein 14B	four and a half LIM domains 3
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Mitochondrial Membrane	Stress Fiber Nucleus Cytoplasm Focal Adhesion Z Disc
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Coregulator Activity Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Heme Biosynthetic Process Nervous System Development Cerebral Cortex Development Neural Precursor Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Muscle Organ Development Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)	Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		235 interacting genes: ABHD16A ABHD5 ACSL5 ADAM33 AGPAT3 AGPAT4 AGR3 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARL8B ARV1 ATP13A1 B4GALT7 BIK BLCAP BMP10 BSG BTN2A2 C10orf67 C14orf180 C1GALT1 C2CD2L CCL4 CD79A CEPT1 CFHR5 CIDEB CLDN10 CLDND2 CMTM5 CMTM8 CNIH2 CNIH3 CNIH4 COMT CPLX4 CREB3 CREB3L1 CXCL16 CYB561 CYB5R3 DEFB103A DEFB103B DGAT2L6 DHRSX EBP EI24 EMC6 EPHX4 ERGIC3 EXTL1 FA2H FADS6 FAM209A FCER1G FHL3 FIS1 FKBP8 FUNDC2 FXYD6-FXYD2 GDAP1 GIMAP1 GPR152 GPX8 GYPA GYPC HEXB HIBADH HIGD1C HMOX1 HMOX2 HSD17B11 HSD17B13 HSD3B1 IER3IP1 IFITM3 INSIG2 ITGAM JAGN1 KCNA1 KCNK1 KHDRBS2 LEPROTL1 LMNA LPAR3 LRCH1 MAL2 MARCHF5 MEOX2 MFSD12 MGAM MID2 MMD2 MS4A13 MS4A4A NAT8 NCALD NDUFA3 NEU1 NINJ1 NINJ2 NIPAL3 ORMDL1 OTULINL PAGE1 PDPN PDZK1IP1 PEX11G PIGF PLLP PLP1 PLP2 PMP22 PNLIPRP1 PPP2R3B PRAF2 PRH1 PRTFDC1 PSMD3 PTPMT1 RABAC1 REEP4 RHD RHOT2 SAR1B SCAMP5 SCN3B SCRG1 SERF1A SERF1B SERP1 SERP2 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SLC10A6 SLC16A10 SLC16A13 SLC18A1 SLC19A3 SLC2A6 SLC30A3 SLC30A8 SLC35A4 SLC35E3 SLC35E4 SLC35F1 SLC35F6 SLC35G1 SLC35H1 SLC39A2 SLC39A7 SLC48A1 SLC61A1 SLC7A8 SMAGP SMPD2 SPRY2 SQLE ST6GAL2 STOM STX12 STX3 STX6 STX8 SUCNR1 SYNGR1 SYNJ2BP TAP1 TAS2R19 TBC1D20 TEX44 THBD TIMM22 TIMM23 TIMMDC1 TLCD1 TM4SF4 TMEM11 TMEM120A TMEM120B TMEM121 TMEM147 TMEM14A TMEM14C TMEM187 TMEM19 TMEM203 TMEM220 TMEM222 TMEM229B TMEM243 TMEM254 TMEM255B TMEM267 TMEM42 TMEM50A TMEM50B TMEM51 TMEM60 TMEM69 TMEM97 TMIE TMUB1 TMX2 TOMM6 TSPAN2 TSPO TVP23B UBE2J1 UBE2J2 UBE3A UBIAD1 UBXN8 UNC50 UNC93A VAMP1 VAMP5 VMA12 VRK2 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC11 ZDHHC22 ZDHHC24 ZFPL1	181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CIMAP1B CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM222B FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GARIN6 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 HYCC1 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PIERCE1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SAXO4 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SPMAP2 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 TLE5 TMEM108 TMEM14B TMSB4X TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587
Entrez ID		81853	2275
HPRD ID		15523	09101
Ensembl ID		ENSG00000137210	ENSG00000183386
Uniprot IDs		A0A087WU83 C9JCY4 C9JQS0 Q9NUH8	Q13643 Q96C98
PDB IDs			1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Endomembrane System Golgi Apparatus Lipid Biosynthetic Process Membrane Organization Cellular Localization Transmembrane Transport Golgi Membrane Mitochondrial Outer Membrane Transmembrane Transporter Activity Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Establishment Of Protein Localization Serine Import Into Mitochondrion Organic Cation Transport SNARE Complex Structural Constituent Of Myelin Sheath Mitochondrial Membrane SNAP Receptor Activity Organelle Fusion Monoatomic Ion Transmembrane Transporter Activity Steroid Biosynthetic Process Amino Acid Transport Myelination Axon Ensheathment Vesicle Fusion Organic Hydroxy Compound Transport Organelle Membrane Fusion Lipid Homeostasis Heme Metabolic Process Pigment Metabolic Process Cholesterol Biosynthetic Process Golgi Trans Cisterna Import Into The Mitochondrion COPII-coated ER To Golgi Transport Vesicle Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Amino Acid Transmembrane Transport Golgi Medial Cisterna SNARE Binding Zinc Ion Transmembrane Transporter Activity Sterol Biosynthetic Process Serine Transport Porphyrin-containing Compound Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Chemical Homeostasis	Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Transcription Coregulator Binding DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Phosphatase Binding Positive Regulation Of Macromolecule Metabolic Process Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Identical Protein Binding SMAD Protein Complex Sequence-specific Double-stranded DNA Binding Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Myelination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axon Ensheathment
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