CCL14 and ACKR2

Number of citations of the paper that reports this interaction (PubMedID 9405404)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CCL14	ACKR2
Description		C-C motif chemokine ligand 14	atypical chemokine receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Membrane Recycling Endosome
	Molecular Function	Cytokine Activity Chemokine Activity CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Receptor Decoy Activity
	Biological Process	Intracellular Calcium Ion Homeostasis Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Intracellular Signal Transduction Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483) Upper eyelid sagging severity ( 24869959)	Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 27863252 32888494)
Interacting Genes		12 interacting genes: ACKR2 AKT2 CCL11 CCL22 CCR1 CCR3 CCR5 DDX39A EXOSC8 NOA1 PIK3R1 RBPMS	25 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 EFNA5 GJA8 MS4A1 NIPAL4 SACM1L SLC13A4 SNCA TMEM167B
Entrez ID		6358	1238
HPRD ID		03231	09095
Ensembl ID		ENSG00000276409	ENSG00000144648
Uniprot IDs		Q16627	O00590
PDB IDs		2Q8R 2Q8T	8GO9 8J8V 8J8Z
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Cytokine-mediated Signaling Pathway Chemotaxis Locomotion Intracellular Signal Transduction Leukocyte Migration Chemokine (C-C Motif) Ligand 5 Binding Intracellular Signaling Cassette Cell Migration Inflammatory Response Myeloid Leukocyte Migration Cell Motility Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Signal Transduction Dendritic Cell Chemotaxis External Side Of Plasma Membrane Eosinophil Chemotaxis G Protein-coupled Receptor Activity Eosinophil Migration Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity CCR Chemokine Receptor Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Cell Killing Response To Stress Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of D-glucose Transmembrane Transport Response To Cytokine Response To Peptide Regulation Of Locomotion Chemokine Activity Cellular Defense Response Cellular Response To High Light Intensity Regulation Of Biological Quality	Chemokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Chemotaxis Eosinophil Migration Locomotion Antimicrobial Humoral Response Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Cell Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Regulation Of Leukocyte Migration Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To External Biotic Stimulus Positive Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Inflammatory Response Regulation Of Locomotion Cell Migration Chemokine Receptor Binding Response To Other Organism Defense Response To Symbiont Defense Response To Other Organism Regulation Of Cell Migration Regulation Of Cell Motility Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Cell Motility Positive Regulation Of Mononuclear Cell Migration CCR1 Chemokine Receptor Binding Regulation Of Lymphocyte Migration Immune Response Extracellular Space Positive Regulation Of Lymphocyte Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Immune System Process Regulation Of Lymphocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis
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