CCL14 and CCR5

Number of citations of the paper that reports this interaction (PMID 11085751)
15

Data Source:
HPRD (in vivo, in vitro)

		CCL14	CCR5
Gene Name		chemokine (C-C motif) ligand 14	chemokine (C-C motif) receptor 5 (gene/pseudogene)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Chemokine Activity	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Cellular Calcium Ion Homeostasis Immune Response Positive Regulation Of Cell Proliferation Cell Chemotaxis	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Maraviroc
Diseases
GWAS			Celiac disease ( 20190752)
Protein-Protein Interactions		7 interactors: ACKR2 AKT2 CCR1 CCR3 CCR5 DDX39A PIK3R1	41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK
Entrez ID		6358	1234
HPRD ID		03231	03223
Ensembl ID		ENSG00000213494	ENSG00000160791
Uniprot IDs		Q16627	A0A502 P51681 Q38L21
PDB IDs		2Q8R 2Q8T	1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cellular Response To Organic Substance Inflammatory Response Cytokine-mediated Signaling Pathway Dendritic Cell Chemotaxis Locomotion Cellular Chemical Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Defense Response Cellular Response To Cytokine Stimulus Chemotaxis Cytosolic Calcium Ion Homeostasis Dendritic Cell Migration Cellular Homeostasis Response To Cytokine Leukocyte Migration Cell Surface Receptor Signaling Pathway Positive Regulation Of Glucose Import Chemical Homeostasis Positive Regulation Of Glucose Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Establishment Of Localization In Cell Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Cellular Defense Response Positive Regulation Of Locomotion Regulation Of Glucose Import Regulation Of Osteoclast Differentiation Cellular Metal Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Cellular Localization Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Immune Response Regulation Of Glucose Transport NFAT Protein Import Into Nucleus Homeostatic Process Viral Process Leukocyte Chemotaxis Ion Homeostasis Regulation Of Myeloid Leukocyte Differentiation Transport Regulation Of Cell Migration Intracellular Transport Transcription Factor Import Into Nucleus Regulation Of Cell Motility Signal Transduction	Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus
Tagcloud ?		17f 28a 6ckine ccl13 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		17f 28a 6ckine ccl13 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?