CCL14 and CCR3

Number of citations of the paper that reports this interaction (PubMedID 11085751)
46

Data Source:
HPRD (in vivo, in vitro)

		CCL14	CCR3
Description		C-C motif chemokine ligand 14	C-C motif chemokine receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Chemokine Activity CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483) Upper eyelid sagging severity ( 24869959)	Arthritis (juvenile idiopathic) ( 33106285) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Behcet's disease ( 33393726 23291587) Bone mineral density (Ward's triangle area) ( 27397699) Celiac disease ( 25920553 20190752 22057235 24999842 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte chemoattractant protein-1 levels ( 23017229) Monocyte count ( 27863252 29403010) Narcolepsy with cataplexy ( 25986216) Obesity-related traits ( 23251661) Pancreatic beta-cell glucose sensitivity ( 32944759) Ulcerative colitis ( 26192919 28067908) White blood cell count (basophil) ( 27863252)
Interacting Genes		12 interacting genes: ACKR2 AKT2 CCL11 CCL22 CCR1 CCR3 CCR5 DDX39A EXOSC8 NOA1 PIK3R1 RBPMS	19 interacting genes: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6358	1232
HPRD ID		03231	03167
Ensembl ID		ENSG00000276409	ENSG00000183625
Uniprot IDs		Q16627	P51677 Q8TDP4 Q8TDP5
PDB IDs		2Q8R 2Q8T	7X9Y
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Cytokine-mediated Signaling Pathway Chemotaxis Locomotion Intracellular Signal Transduction Leukocyte Migration Chemokine (C-C Motif) Ligand 5 Binding Intracellular Signaling Cassette Cell Migration Inflammatory Response Myeloid Leukocyte Migration Cell Motility Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Signal Transduction Dendritic Cell Chemotaxis External Side Of Plasma Membrane Eosinophil Chemotaxis G Protein-coupled Receptor Activity Eosinophil Migration Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity CCR Chemokine Receptor Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Cell Killing Response To Stress Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of D-glucose Transmembrane Transport Response To Cytokine Response To Peptide Regulation Of Locomotion Chemokine Activity Cellular Defense Response Cellular Response To High Light Intensity Regulation Of Biological Quality	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Granulocyte Chemotaxis Locomotion Defense Response To Symbiont Inflammatory Response Defense Response To Other Organism Granulocyte Migration Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Eosinophil Migration Leukocyte Migration Myeloid Leukocyte Migration Response To Other Organism Immune Response Cell Migration Response To External Biotic Stimulus Defense Response Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Locomotion Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Extracellular Space Cell Surface Receptor Signaling Pathway Extracellular Region Response To Stress Regulation Of Lymphocyte Chemotaxis Cell-cell Signaling Signaling Cell Communication Regulation Of Leukocyte Migration Regulation Of Cell Shape Positive Regulation Of Leukocyte Migration Signal Transduction Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Calcium Ion Transport Intracellular Calcium Ion Homeostasis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?