CCL7 and ACKR4

Number of citations of the paper that reports this interaction (PubMedID 10734104)
0

Data Source:
HPRD (in vitro)

		CCL7	ACKR4
Description		C-C motif chemokine ligand 7	atypical chemokine receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Recycling Endosome
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding
	Biological Process	Monocyte Chemotaxis Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Canonical NF-kappaB Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Eosinophil Chemotaxis Positive Regulation Of Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Natural Killer Cell Chemotaxis	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Vesicle-mediated Transport Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 21102463 22412388 28067908) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 CXCL6 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 TLE5 UBQLN1 UBQLN2 XCL2	11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6354	51554
HPRD ID		01150	07298
Ensembl ID		ENSG00000108688	ENSG00000129048
Uniprot IDs		P80098	Q9NPB9
PDB IDs		1BO0 1NCV 4ZKC 7S58 7S59 7SCU 8FJ3 8FK6 8FK8 8JPS
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway C-C Chemokine Binding Chemokine Receptor Activity C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Cell Surface Receptor Signaling Pathway Calcium-mediated Signaling Endopeptidase Activity Metalloendopeptidase Activity Cell Motility G Protein-coupled Receptor Signaling Pathway Cellular Response To UV-A G Protein-coupled Receptor Activity Metallopeptidase Activity Response To UV-A Serine-type Endopeptidase Activity Chemokine (C-C Motif) Ligand 5 Binding Inflammatory Response Immune System Process External Side Of Plasma Membrane Immune Response Response To Stress Extracellular Structure Organization Extracellular Matrix Organization Leukocyte Chemotaxis Chemokine Binding Intracellular Signaling Cassette Response To Amyloid-beta Defense Response Extracellular Matrix Leukocyte Migration Peptidase Activity Cellular Response To UV Signal Transduction Dendritic Cell Chemotaxis Positive Regulation Of ERAD Pathway Mononuclear Cell Migration Proteolysis Cellular Response To Light Stimulus Plasma Membrane Response To Cytokine Dendritic Cell Migration	Eosinophil Migration Eosinophil Chemotaxis Chemokine Activity CCR Chemokine Receptor Binding Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Leukocyte Chemotaxis Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Leukocyte Migration Humoral Immune Response Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Inflammatory Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Leukocyte Migration Defense Response To Symbiont Defense Response To Other Organism Killing Of Cells Of Another Organism G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Leukocyte Migration Cell Migration Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Migration Cell Killing Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Response To Other Organism Chemokine Receptor Binding Mononuclear Cell Migration Immune Response Response To External Biotic Stimulus Defense Response Positive Regulation Of Chemotaxis CCR10 Chemokine Receptor Binding Extracellular Space Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Lymphocyte Migration Intracellular Calcium Ion Homeostasis Regulation Of Chemotaxis Calcium Ion Homeostasis
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