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CCL7 and CCR5
Number of citations of the paper that reports this interaction (PubMedID
10477718
)
0
Data Source:
HPRD
(in vitro)
CCL7
CCR5
Description
C-C motif chemokine ligand 7
C-C motif chemokine receptor 5
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Endosome
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Molecular Function
Cytokine Activity
Protein Binding
Chemokine Activity
Heparin Binding
CCR1 Chemokine Receptor Binding
CCR2 Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Virus Receptor Activity
Actin Binding
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
G Protein-coupled Receptor Activity
Chemokine Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Identical Protein Binding
Chemokine (C-C Motif) Ligand 5 Binding
Biological Process
Monocyte Chemotaxis
Intracellular Calcium Ion Homeostasis
Chemotaxis
Inflammatory Response
Immune Response
Cytoskeleton Organization
Signal Transduction
Canonical NF-kappaB Signal Transduction
Cell-cell Signaling
Regulation Of Cell Shape
Response To Gamma Radiation
Signal Transduction Involved In Regulation Of Gene Expression
Positive Regulation Of Cell Migration
Eosinophil Chemotaxis
Positive Regulation Of Inflammatory Response
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemokine-mediated Signaling Pathway
Cellular Response To Ethanol
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Natural Killer Cell Chemotaxis
MAPK Cascade
Dendritic Cell Chemotaxis
Calcium Ion Transport
Apoptotic Process
Chemotaxis
Defense Response
Inflammatory Response
Immune Response
Cellular Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Calcium-mediated Signaling
Signaling
Symbiont Entry Into Host Cell
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Response To Cholesterol
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Negative Regulation Of Macrophage Apoptotic Process
Pathways
Chemokine receptors bind chemokines
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
Maraviroc
AMD-070
CCR5 mAb
Leronlimab
Aplaviroc
Vicriviroc
Ibalizumab
INCB-9471
Diseases
GWAS
Blood protein levels (
30072576
)
Crohn's disease (
21102463
22412388
28067908
)
Gut microbiota (functional units) (
27694959
)
Inflammatory bowel disease (
28067908
)
Blood protein levels in cardiovascular risk (
28369058
)
Celiac disease (
20190752
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
26192919
)
Type 1 diabetes (
25751624
)
Ulcerative colitis (
26192919
28067908
)
Interacting Genes
18 interacting genes:
ACKR1
ACKR2
ACKR4
CCR1
CCR10
CCR3
CCR5
CXCL6
FEZ1
MMP1
MMP13
MMP14
MMP2
MMP3
TLE5
UBQLN1
UBQLN2
XCL2
43 interacting genes:
AFP
ARL6IP5
ARRB1
CCL11
CCL13
CCL14
CCL16
CCL2
CCL3
CCL3L1
CCL3L3
CCL4
CCL5
CCL7
CCL8
CD4
CST9L
CTBP2
CXCR4
DNM2
EMP1
ETV5
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GRK2
GRK3
IL24
JAK1
JAK2
LCK
ORM1
PRAF2
PSMA5
PTK2
PTK2B
SLC20A2
STAT1
STAT3
STAT5A
TXK
Entrez ID
6354
1234
HPRD ID
01150
03223
Ensembl ID
ENSG00000108688
ENSG00000160791
Uniprot IDs
P80098
P51681
Q38L21
PDB IDs
1BO0
1NCV
4ZKC
7S58
7S59
7SCU
8FJ3
8FK6
8FK8
8JPS
2L87
2MZX
2RLL
2RRS
4MBS
5UIW
5YD3
5YD4
5YD5
5YY4
6FGP
6MEO
6MET
7F1Q
7F1R
7F1S
7NJZ
7NW3
7O7F
8AS2
8AS3
Enriched GO Terms of Interacting Partners
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Chemokine-mediated Signaling Pathway
C-C Chemokine Binding
Chemokine Receptor Activity
C-C Chemokine Receptor Activity
Cell Chemotaxis
Chemotaxis
Locomotion
Cytokine-mediated Signaling Pathway
Collagen Catabolic Process
Extracellular Matrix Disassembly
Collagen Metabolic Process
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell Migration
Cell Surface Receptor Signaling Pathway
Calcium-mediated Signaling
Endopeptidase Activity
Metalloendopeptidase Activity
Cell Motility
G Protein-coupled Receptor Signaling Pathway
Cellular Response To UV-A
G Protein-coupled Receptor Activity
Metallopeptidase Activity
Response To UV-A
Serine-type Endopeptidase Activity
Chemokine (C-C Motif) Ligand 5 Binding
Inflammatory Response
Immune System Process
External Side Of Plasma Membrane
Immune Response
Response To Stress
Extracellular Structure Organization
Extracellular Matrix Organization
Leukocyte Chemotaxis
Chemokine Binding
Intracellular Signaling Cassette
Response To Amyloid-beta
Defense Response
Extracellular Matrix
Leukocyte Migration
Peptidase Activity
Cellular Response To UV
Signal Transduction
Dendritic Cell Chemotaxis
Positive Regulation Of ERAD Pathway
Mononuclear Cell Migration
Proteolysis
Cellular Response To Light Stimulus
Plasma Membrane
Response To Cytokine
Dendritic Cell Migration
Chemokine-mediated Signaling Pathway
CCR Chemokine Receptor Binding
Cytokine-mediated Signaling Pathway
Chemokine Activity
G Protein-coupled Receptor Signaling Pathway
Eosinophil Chemotaxis
Eosinophil Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Antimicrobial Humoral Response
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cell Chemotaxis
Cytokine Activity
CCR5 Chemokine Receptor Binding
Immune System Process
Immune Response
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Migration
Humoral Immune Response
Regulation Of Cell Motility
Signal Transduction
Regulation Of Locomotion
Granulocyte Chemotaxis
Leukocyte Migration
Chemotaxis
Granulocyte Migration
Defense Response
Cell Migration
Leukocyte Chemotaxis
Inflammatory Response
Locomotion
Response To Other Organism
Response To External Biotic Stimulus
Cell Motility
Regulation Of Lymphocyte Chemotaxis
Myeloid Leukocyte Migration
Defense Response To Symbiont
Positive Regulation Of Natural Killer Cell Chemotaxis
Defense Response To Other Organism
Guanyl Nucleotide Binding
CCR1 Chemokine Receptor Binding
G Protein-coupled Receptor Binding
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Lymphocyte Chemotaxis
Cell Surface Receptor Signaling Pathway Via STAT
Non-membrane Spanning Protein Tyrosine Kinase Activity
G-protein Beta/gamma-subunit Complex Binding
Protein Kinase Activity
Interleukin-9-mediated Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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