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BGN and COL2A1
Number of citations of the paper that reports this interaction (PubMedID
2059554
)
0
Data Source:
HPRD
(in vitro)
BGN
COL2A1
Description
biglycan
collagen type II alpha 1 chain
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Lumen
Cell Surface
Transport Vesicle
Extracellular Matrix
Sarcolemma
Lysosomal Lumen
Extracellular Exosome
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type II Trimer
Collagen Type XI Trimer
Basement Membrane
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Extracellular Matrix
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Glycosaminoglycan Binding
Cytokine Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Extracellular Matrix Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
MHC Class II Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Proteoglycan Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Blood Vessel Remodeling
Bone Development
Articular Cartilage Development
Skeletal System Development
Cartilage Condensation
Ossification
Tissue Homeostasis
Endochondral Ossification
Chondrocyte Differentiation
Heart Morphogenesis
Proteoglycan Metabolic Process
Central Nervous System Development
Visual Perception
Sensory Perception Of Sound
Regulation Of Gene Expression
Collagen Fibril Organization
Notochord Development
Limb Morphogenesis
Inner Ear Morphogenesis
Animal Organ Development
Skeletal System Morphogenesis
System Development
Inner Ear Development
Cartilage Development
Roof Of Mouth Development
Limb Bud Formation
Embryonic Skeletal Joint Morphogenesis
Bone Development
Cartilage Development Involved In Endochondral Bone Morphogenesis
Otic Vesicle Development
Cellular Response To BMP Stimulus
Anterior Head Development
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Glycosaminoglycan-protein linkage region biosynthesis
CS-GAG biosynthesis
DS-GAG biosynthesis
CS/DS degradation
ECM proteoglycans
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Collagenase clostridium histolyticum
Diseases
Osteoarthritis with mild chondrodysplasia
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
GWAS
Lymphocyte count (
32888494
)
Macular thickness (
30535121
)
Neutrophil percentage of white cells (
32888494
)
Retinal detachment or retinal break (
31816047
)
Rheumatoid arthritis (
30891314
)
Triglyceride levels (
32902719
)
Interacting Genes
21 interacting genes:
-
APOB
APP
BMP4
CCN4
COL18A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL6A1
DAG1
ELN
HSPB2
JPH3
MFAP2
PLA2G1B
TGFB1
THBS1
TNF
33 interacting genes:
ANXA5
BGN
BMP2
C1QA
CHAD
COL6A1
COL9A2
COL9A3
COMP
DDR1
FGF7
FN1
HTRA1
HYAL1
ITGA2B
KEAP1
LOXL4
MAG
MATN1
MMP1
MMP13
PCOLCE
PDGFA
PDGFB
PDIA2
PKD1
PRELP
RELA
SPARC
TGFB1
TGFBI
THBS1
TNFRSF10A
Entrez ID
633
1280
HPRD ID
02359
00361
Ensembl ID
ENSG00000182492
ENSG00000139219
Uniprot IDs
B4DNL4
P21810
P02458
PDB IDs
1U5M
2FSE
2SEB
5NIR
5OCX
5OCY
6BIN
6HG7
6NIX
7NZE
Enriched GO Terms of Interacting Partners
?
Endoplasmic Reticulum Lumen
Extracellular Matrix
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Extracellular Region
Extracellular Matrix Structural Constituent
Platelet-derived Growth Factor Binding
Anatomical Structure Morphogenesis
Collagen Trimer
Animal Organ Morphogenesis
Basement Membrane
Extracellular Space
Response To Mechanical Stimulus
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Smooth Muscle Cell Proliferation
Cellular Response To Growth Factor Stimulus
Negative Regulation Of MiRNA Transcription
Extracellular Matrix Assembly
Cellular Response To Amino Acid Stimulus
Angiogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To Growth Factor
Fibrillar Collagen Trimer
Developmental Process
Response To Amino Acid
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Collagen-activated Signaling Pathway
Collagen Fibril Organization
Response To Xenobiotic Stimulus
Heparin Binding
Tube Morphogenesis
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Primary MiRNA Processing
Collagen Type I Trimer
System Development
Bone Development
Regulation Of MiRNA Transcription
Animal Organ Development
Response To Activity
Skeletal System Development
Positive Regulation Of Cell Migration
System Process
Positive Regulation Of Cell Motility
Regulation Of MiRNA Metabolic Process
Positive Regulation Of Locomotion
Positive Regulation Of Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Positive Regulation Of Mononuclear Cell Migration
Cell Surface Receptor Signaling Pathway
Extracellular Matrix
Extracellular Region
Collagen Binding
Extracellular Matrix Structural Constituent
Extracellular Space
Animal Organ Development
Cartilage Development
Extracellular Matrix Binding
Platelet Alpha Granule Lumen
Developmental Process
Cell Surface
Extracellular Matrix Organization
Extracellular Structure Organization
Animal Organ Morphogenesis
Endoplasmic Reticulum Lumen
Response To Mechanical Stimulus
Response To Wounding
Anatomical Structure Morphogenesis
Bone Development
Heparin Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Glial Cell Differentiation
Basement Membrane
Positive Regulation Of Cell Motility
Platelet-derived Growth Factor Binding
Golgi Lumen
Tube Morphogenesis
Positive Regulation Of Locomotion
Angiogenesis
Regulation Of Cell Adhesion
Extracellular Exosome
Proteoglycan Binding
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Skin Development
Regulation Of Anatomical Structure Morphogenesis
Cell Adhesion
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Bone Mineralization
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Fibroblast Proliferation
Chondrocyte Differentiation
Positive Regulation Of MiRNA Metabolic Process
Positive Regulation Of Gliogenesis
Positive Regulation Of Phosphorylation
Collagen Metabolic Process
Regulation Of Extracellular Matrix Organization
Regulation Of Glial Cell Differentiation
Connective Tissue Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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