BGN and PLA2G1B

Number of citations: 0 (PubMedID 9848887)
Data Source: HPRD (in vitro)

		BGN	PLA2G1B
Name		biglycan	phospholipase A2 group IB
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding	Phospholipase A2 Activity Signaling Receptor Binding Calcium Ion Binding Phospholipid Binding Hydrolase Activity Bile Acid Binding Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Blood Vessel Remodeling Bone Development Articular Cartilage Development	Innate Immune Response In Mucosa Neutrophil Mediated Immunity Lipid Metabolic Process Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Lipid Catabolic Process Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of D-glucose Import Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Positive Regulation Of Fibroblast Proliferation Arachidonate Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Podocyte Apoptotic Process
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Developmental Lineage of Pancreatic Acinar Cells
Drugs		None	Fluocinolone acetonide Sulfasalazine Azelastine Hexane-1,6-Diol N-Tridecanoic Acid Cholic Acid P-Anisic Acid Heptanoic acid 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Pyruvaldehyde Lpc-Ether Niflumic acid PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL Medical Cannabis
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 )
Interacting Genes		21 interacting genes: - APOB APP BMP4 CCN4 COL18A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL6A1 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 THBS1 TNF	5 interacting genes: BGN CSF3R PLA2G2A PLAA SOCS2
Entrez ID		633	5319
HPRD ID		02359	01396
Ensembl ID		ENSG00000182492	ENSG00000170890
Uniprot IDs		B4DNL4 P21810	P04054
PDB IDs		Not available	3ELO 6Q42
GO Terms Enriched among Interactors		Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Platelet-derived Growth Factor Binding Anatomical Structure Morphogenesis Collagen Trimer Animal Organ Morphogenesis Basement Membrane Extracellular Space Response To Mechanical Stimulus Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Growth Factor Stimulus Negative Regulation Of MiRNA Transcription Extracellular Matrix Assembly Cellular Response To Amino Acid Stimulus Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Growth Factor Fibrillar Collagen Trimer Developmental Process Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Fibril Organization Response To Xenobiotic Stimulus Heparin Binding Tube Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Primary MiRNA Processing Collagen Type I Trimer System Development Bone Development Regulation Of MiRNA Transcription Animal Organ Development Response To Activity Skeletal System Development Positive Regulation Of Cell Migration System Process Positive Regulation Of Cell Motility Regulation Of MiRNA Metabolic Process Positive Regulation Of Locomotion Positive Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Mononuclear Cell Migration Cell Surface Receptor Signaling Pathway	Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Articular Cartilage Development Defense Response Regulation Of Developmental Process Granulocyte Colony-stimulating Factor Binding Amelogenesis Regulation Of Neutrophil Activation Intestinal Stem Cell Homeostasis Calcium-dependent Phospholipase A2 Activity Phospholipid Metabolic Process Positive Regulation Of Developmental Process Growth Hormone Receptor Binding Regulation Of Developmental Growth Regulation Of Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Erythropoietin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Growth Hormone Receptor Signaling Pathway JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Positive Regulation Of Neuron Migration Positive Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Ubiquitin Recycling Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Protein Polyubiquitination Phospholipase A2 Activator Activity Regulation Of Protein K63-linked Ubiquitination Low-density Lipoprotein Particle Remodeling Insulin-like Growth Factor Receptor Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mammary Gland Alveolus Development Regulation Of Cell Growth Cytokine-mediated Signaling Pathway Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Positive Regulation Of Dendrite Extension Arachidonate Secretion