BGN and CCN4

Number of citations of the paper that reports this interaction (PubMedID 11598131)
0

Data Source:
HPRD (in vitro)

		BGN	CCN4
Description		biglycan	cellular communication network factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Cytosol Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding	Integrin Binding Protein Binding Heparin Binding
	Biological Process	Blood Vessel Remodeling Bone Development Articular Cartilage Development	Osteoblast Differentiation Regulation Of Cytokine Production Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Smooth Muscle Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Osteoclast Differentiation Negative Regulation Of Chondrocyte Differentiation Glucose Homeostasis Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Bone Development Positive Regulation Of Wound Healing
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS			Asthma ( 34103634)
Interacting Genes		21 interacting genes: - APOB APP BMP4 CCN4 COL18A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL6A1 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 THBS1 TNF	4 interacting genes: BGN DCN HOXA1 OTX1
Entrez ID		633	8840
HPRD ID		02359	16019
Ensembl ID		ENSG00000182492	ENSG00000104415
Uniprot IDs		B4DNL4 P21810	O95388
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Platelet-derived Growth Factor Binding Anatomical Structure Morphogenesis Collagen Trimer Animal Organ Morphogenesis Basement Membrane Extracellular Space Response To Mechanical Stimulus Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Growth Factor Stimulus Negative Regulation Of MiRNA Transcription Extracellular Matrix Assembly Cellular Response To Amino Acid Stimulus Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Growth Factor Fibrillar Collagen Trimer Developmental Process Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Fibril Organization Response To Xenobiotic Stimulus Heparin Binding Tube Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Primary MiRNA Processing Collagen Type I Trimer System Development Bone Development Regulation Of MiRNA Transcription Animal Organ Development Response To Activity Skeletal System Development Positive Regulation Of Cell Migration System Process Positive Regulation Of Cell Motility Regulation Of MiRNA Metabolic Process Positive Regulation Of Locomotion Positive Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Mononuclear Cell Migration Cell Surface Receptor Signaling Pathway	Extracellular Matrix Structural Constituent Conferring Compression Resistance Glycosaminoglycan Binding Extracellular Matrix Binding Lysosomal Lumen Semicircular Canal Formation Diencephalon Morphogenesis Golgi Lumen Abducens Nerve Formation Optokinetic Behavior Metencephalon Development Articular Cartilage Development Axonemal Central Apparatus Assembly Positive Regulation Of Mitochondrial Depolarization Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Radial Spoke Positive Regulation Of Membrane Depolarization Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Sperm Head-tail Coupling Apparatus Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Extracellular Matrix Positive Regulation Of Mitochondrial Fission Anatomical Structure Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Morphogenesis Regulation Of Mitochondrial Depolarization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cochlea Morphogenesis Regulation Of Mitochondrial Fission
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