SCD and TIMMDC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCD	TIMMDC1
Description		stearoyl-CoA desaturase	translocase of inner mitochondrial membrane domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	Stearoyl-CoA 9-desaturase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Palmitoyl-CoA 9-desaturase Activity Metal Ion Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis Monounsaturated Fatty Acid Biosynthetic Process	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Complex I biogenesis
Drugs
Diseases
GWAS		Macular thickness ( 30535121) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Vaccenic acid (18:1n-7) levels ( 28298293) White blood cell count (basophil) ( 27863252)	Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)
Interacting Genes		44 interacting genes: APP AQP6 CD207 CD33 CERS4 CLEC12B CREB3L1 CYB561 CYB5A CYBC1 ERGIC3 FAM209A GJB1 GPR152 GPR42 GPX8 HSD17B13 JAGN1 KCNJ6 MARCHF5 MCFD2 MGST3 MTIF3 NEDD4L PVR REEP2 RETREG3 RNF5 SCN3B SEC11C SLC10A6 SLC18A1 SLC35H1 SLC71A2 SLC7A14 SPAG4 STOM TIMMDC1 TLCD4 TMEM30B TMPRSS2 TMX2 UBC VMA21	82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4
Entrez ID		6319	51300
HPRD ID		04941	12817
Ensembl ID		ENSG00000099194	ENSG00000113845
Uniprot IDs		O00767	C9JU35 Q9NPL8
PDB IDs		4ZYO
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transport Sodium Channel Inhibitor Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment
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