SCD and CYB5A

Number of citations of the paper that reports this interaction (PMID 6102994)
10

Data Source:
HPRD (in vitro)

		SCD	CYB5A
Gene Name		stearoyl-CoA desaturase (delta-9-desaturase)	cytochrome b5 type A (microsomal)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Stearoyl-CoA 9-desaturase Activity Iron Ion Binding	Aldo-keto Reductase (NADP) Activity Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Fatty Acid Biosynthetic Process Oxidation-reduction Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process L-ascorbic Acid Metabolic Process Small Molecule Metabolic Process Response To Cadmium Ion Oxidation-reduction Process Hydrogen Ion Transmembrane Transport
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs			Heme Dimethyl Propionate Ester Heme
Diseases
GWAS		Metabolic traits ( 21886157) Palmitic acid (16:0) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		3 interactors: APP CYB5A NEDD4L	15 interactors: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 CYP4F2 POR SCD UGT1A4
Entrez ID		6319	1528
HPRD ID		04941	08941
Ensembl ID		ENSG00000099194	ENSG00000166347
Uniprot IDs		O00767	P00167
PDB IDs			2I96
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Caveolin-mediated Endocytosis Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Response To Metal Ion Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Cellular Metal Ion Homeostasis Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Cellular Cation Homeostasis Cellular Ion Homeostasis Neuron Remodeling Metal Ion Homeostasis Response To Inorganic Substance Negative Regulation Of Sodium Ion Transport Cellular Chemical Homeostasis Negative Regulation Of Potassium Ion Transmembrane Transport L-ascorbic Acid Metabolic Process Cellular Sodium Ion Homeostasis Ion Homeostasis Ventricular Cardiac Muscle Cell Action Potential Cellular Copper Ion Homeostasis Monovalent Inorganic Cation Transport Regulation Of Protein Localization To Cell Surface Cellular Homeostasis Negative Regulation Of Potassium Ion Transport Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Repolarization Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Copper Ion Homeostasis Suckling Behavior Sodium Ion Homeostasis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Chemical Homeostasis Positive Regulation Of Cation Channel Activity Mating Behavior Positive Regulation Of Sodium Ion Transport Cardiac Muscle Cell Action Potential	Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Drug Metabolic Process Epoxygenase P450 Pathway Oxidation-reduction Process Exogenous Drug Catabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Drug Catabolic Process Arachidonic Acid Metabolic Process Carboxylic Acid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Monocarboxylic Acid Metabolic Process Unsaturated Fatty Acid Metabolic Process Lipid Metabolic Process Long-chain Fatty Acid Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Response To Drug Omega-hydroxylase P450 Pathway Catabolic Process Cellular Lipid Metabolic Process Demethylation Coumarin Metabolic Process Isoprenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Alkaloid Metabolic Process Toxin Metabolic Process Oxidative Demethylation Flavonoid Metabolic Process Vitamin Metabolic Process Alkaloid Catabolic Process Pressure Natriuresis Leukotriene B4 Catabolic Process Cellular Metabolic Process Cellular Response To Stimulus Porphyrin-containing Compound Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Long-chain Fatty Acid Catabolic Process Response To Herbicide Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Lipid Catabolic Process Cellular Ketone Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Tetrapyrrole Metabolic Process Lipid Biosynthetic Process Vitamin D Metabolic Process
Tagcloud ?		aplastic bm caa cellularity conselling cytogenetically dysplastic erbb erythroleukamia familial fanconi fdrs folic fragility generations hematologically leukemias lymphocyte megakaryocystic megakaryocytes megakaryopoiesis monosomy myeloleukemias parents pb preleukemia rearrangement siblings unstability	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Difference) ?		aplastic bm caa cellularity conselling cytogenetically dysplastic erbb erythroleukamia familial fanconi fdrs folic fragility generations hematologically leukemias lymphocyte megakaryocystic megakaryocytes megakaryopoiesis monosomy myeloleukemias parents pb preleukemia rearrangement siblings unstability	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Intersection) ?