SCD and JAGN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCD	JAGN1
Description		stearoyl-CoA desaturase	jagunal vesicle mediated transporter 1
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GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Stearoyl-CoA 9-desaturase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Palmitoyl-CoA 9-desaturase Activity Metal Ion Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis Monounsaturated Fatty Acid Biosynthetic Process	Immune System Process Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Response To Glucose Protein Transport Vesicle-mediated Transport Insulin Secretion Neutrophil Differentiation Response To Endoplasmic Reticulum Stress Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Insulin Metabolic Process Neutrophil Migration
Pathways		Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Macular thickness ( 30535121) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Vaccenic acid (18:1n-7) levels ( 28298293) White blood cell count (basophil) ( 27863252)
Interacting Genes		44 interacting genes: APP AQP6 CD207 CD33 CERS4 CLEC12B CREB3L1 CYB561 CYB5A CYBC1 ERGIC3 FAM209A GJB1 GPR152 GPR42 GPX8 HSD17B13 JAGN1 KCNJ6 MARCHF5 MCFD2 MGST3 MTIF3 NEDD4L PVR REEP2 RETREG3 RNF5 SCN3B SEC11C SLC10A6 SLC18A1 SLC35H1 SLC71A2 SLC7A14 SPAG4 STOM TIMMDC1 TLCD4 TMEM30B TMPRSS2 TMX2 UBC VMA21	128 interacting genes: AGPAT4 APP AQP6 ARL13B ARLN BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC10A6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 SSMEM1 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VMA12 VSIG4 VTI1B
Entrez ID		6319	84522
HPRD ID		04941	13749
Ensembl ID		ENSG00000099194	ENSG00000171135
Uniprot IDs		O00767	Q8N5M9
PDB IDs		4ZYO	6WVD
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transport Sodium Channel Inhibitor Activity	Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex Membrane Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Vesicle Fusion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Organization Golgi Vesicle Transport Membrane Docking Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endomembrane System Chloride Channel Inhibitor Activity Vesicle Docking Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Organization Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane External Side Of Plasma Membrane Establishment Of Protein Localization Cellular Localization Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex FFAT Motif Binding Lipid Biosynthetic Process Zymogen Granule Membrane Endoplasmic Reticulum-autophagosome Adaptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Vesicle Positive Regulation Of Mitochondrial Fission Synaptic Vesicle COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization
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