SERPINB4 and CTSG

Number of citations of the paper that reports this interaction (PMID 12949073)
3

Data Source:
BioGRID (pull down)

		SERPINB4	CTSG
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 4	cathepsin G
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface Secretory Granule Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Enzyme Binding	Serine-type Endopeptidase Activity Heparin Binding Peptidase Activity
	Biological Process	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis	Angiotensin Maturation Proteolysis Immune Response Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Response To Lipopolysaccharide Negative Regulation Of Growth Of Symbiont In Host Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Peptide hormone metabolism Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Degradation of the extracellular matrix
Drugs			Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CTSG CTSS MAPK8	28 interactors: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBB2IP F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NL PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		6318	1511
HPRD ID		02746	00289
Ensembl ID		ENSG00000206073	ENSG00000100448
Uniprot IDs		P48594	P08311
PDB IDs			1AU8 1CGH 1KYN 1T32
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune Response Extracellular Matrix Disassembly Regulation Of Immune Response Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune Response Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Defense Response Neutrophil Mediated Killing Of Gram-positive Bacterium Basement Membrane Disassembly Regulation Of Innate Immune Response Response To Lipopolysaccharide JUN Phosphorylation Response To Molecule Of Bacterial Origin Positive Regulation Of Deacetylase Activity Extracellular Matrix Organization Extracellular Structure Organization Immune System Process Positive Regulation Of Determination Of Dorsal Identity Killing By Host Of Symbiont Cells Immune Response-regulating Signaling Pathway Response To Bacterium Response To Organic Substance Cellular Response To Thyroid Hormone Stimulus Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Cellular Response To Nitric Oxide Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Response To Nitric Oxide Response To Thyroid Hormone Basement Membrane Organization Neutrophil Mediated Immunity Response To Other Organism Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Reactive Nitrogen Species Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Biotic Stimulus Killing Of Cells Of Other Organism Response To Stress Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Defense Response To Fungus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Lipid Interaction With Symbiont Leukocyte Mediated Cytotoxicity	Cell Activation Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Inflammatory Response Blood Coagulation Hemostasis Wound Healing Response To Wounding Negative Regulation Of Endopeptidase Activity Response To Stress Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Platelet Activation Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Thrombin Receptor Signaling Pathway Regulation Of Protein Processing Response To Stimulus Regulation Of Cellular Protein Metabolic Process Defense Response Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Migration Platelet Degranulation Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Transport Regulation Of Catalytic Activity Regulation Of Blood Coagulation Negative Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Regulation Of Chemotaxis Response To Cytokine Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Blood Circulation Response To Biotic Stimulus Secretion By Cell Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Cell Migration Cellular Chemical Homeostasis Positive Regulation Of Cell Motility
Tagcloud ?			aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Difference) ?			aaa aaas aneurysms ang angiotensin aortas aortic cacl2 catg cathepsin converting elastin elastinolytic gelatin immunofluorescent indices indirectly ldlr lesion littermate metalloproteinases mm2 participates periaortic producing protease smcs untested zymogram
Tagcloud (Intersection) ?