SERPINB4 and CTSS

Number of citations of the paper that reports this interaction (PMID 10852705)
4

Data Source:
HPRD (in vitro)

		SERPINB4	CTSS
Gene Name		serpin peptidase inhibitor, clade B (ovalbumin), member 4	cathepsin S
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Lysosome Membrane Endolysosome Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Enzyme Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Laminin Binding Proteoglycan Binding
	Biological Process	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis	Toll-like Receptor Signaling Pathway Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Basement Membrane Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Positive Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways			Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System
Drugs			Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE 2-[(2\',3\',4\'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		3 interactors: CTSG CTSS MAPK8	8 interactors: BGLAP CST3 CST5 KNG1 PLCG1 SERPINB3 SERPINB4 SLPI
Entrez ID		6318	1520
HPRD ID		02746	00292
Ensembl ID		ENSG00000206073	ENSG00000163131
Uniprot IDs		P48594	P25774
PDB IDs			1BXF 1GLO 1MS6 1NPZ 1NQC 2C0Y 2F1G 2FQ9 2FRA 2FRQ 2FT2 2FUD 2FYE 2G6D 2G7Y 2H7J 2HH5 2HHN 2HXZ 2OP3 2R9M 2R9N 2R9O 3IEJ 3KWN 3MPE 3MPF 3N3G 3N4C 3OVX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune Response Extracellular Matrix Disassembly Regulation Of Immune Response Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune Response Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Defense Response Neutrophil Mediated Killing Of Gram-positive Bacterium Basement Membrane Disassembly Regulation Of Innate Immune Response Response To Lipopolysaccharide JUN Phosphorylation Response To Molecule Of Bacterial Origin Positive Regulation Of Deacetylase Activity Extracellular Matrix Organization Extracellular Structure Organization Immune System Process Positive Regulation Of Determination Of Dorsal Identity Killing By Host Of Symbiont Cells Immune Response-regulating Signaling Pathway Response To Bacterium Response To Organic Substance Cellular Response To Thyroid Hormone Stimulus Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Cellular Response To Nitric Oxide Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Response To Nitric Oxide Response To Thyroid Hormone Basement Membrane Organization Neutrophil Mediated Immunity Response To Other Organism Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Reactive Nitrogen Species Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Biotic Stimulus Killing Of Cells Of Other Organism Response To Stress Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Defense Response To Fungus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Lipid Interaction With Symbiont Leukocyte Mediated Cytotoxicity	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Tissue Remodeling Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Collagen Catabolic Process Response To Vitamin K Regulation Of Collagen Catabolic Process Regulation Of Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Metabolic Process Regulation Of Blood Vessel Remodeling Response To Hydroxyisoflavone Negative Regulation Of Multicellular Organismal Metabolic Process Regulation Of Cellular Process Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Glycoprotein Metabolic Process Extracellular Fibril Organization Blood Coagulation, Intrinsic Pathway Positive Regulation Of Urine Volume Response To Gravity Negative Regulation Of Tissue Remodeling Cellular Response To Vitamin D Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Renal Sodium Excretion Defense Response Blood Coagulation Regulation Of Excretion Hemostasis Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Phospholipid Catabolic Process Osteoblast Development Response To Epidermal Growth Factor Regulation Of Extracellular Matrix Disassembly
Tagcloud ?			amounts bacteriuria capability capacitance capacitive consuming demand dissolved distinguishing exponential feasible fem finite gave giving ionic liquids measurable portable proposes sensor simulations solutions tangible top touch urine utis volumes
Tagcloud (Difference) ?			amounts bacteriuria capability capacitance capacitive consuming demand dissolved distinguishing exponential feasible fem finite gave giving ionic liquids measurable portable proposes sensor simulations solutions tangible top touch urine utis volumes
Tagcloud (Intersection) ?