ATXN2 and RBFOX1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
HPRD (two hybrid, in vivo)

		ATXN2	RBFOX1
Description		ataxin 2	RNA binding fox-1 homolog 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Stress Granule Membrane Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex	Nucleus Cytoplasm Trans-Golgi Network Cytoplasmic Stress Granule Nuclear Stress Granule
	Molecular Function	RNA Binding MRNA Binding Epidermal Growth Factor Receptor Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Receptor Internalization Regulation Of Translation RNA Metabolic Process P-body Assembly Stress Granule Assembly RNA Transport	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing Regulation Of RNA Splicing RNA Transport
Pathways			MECP2 regulates transcription factors
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Alopecia areata ( 25608926) Apolipoprotein B levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 30929738 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Beta-2 microglubulin plasma levels ( 23417110) Blood osmolality (transformed sodium) ( 28360221) Blood pressure ( 21909110) Body mass index ( 26426971) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Caffeine consumption from coffee or tea ( 33287642) Celiac disease ( 18311140 22057235) Chronic kidney disease ( 20383146) Coronary artery disease ( 29212778) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 19430483 26390057 27736895) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Estimated glomerular filtration rate ( 31015462 31152163) Gastroesophageal reflux disease ( 31527586) Glaucoma (primary open-angle) ( 26752265 33627673) Glomerular filtration rate (cystatin C) ( 28452372) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) Heart failure ( 31919418) Hematocrit ( 19862010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 31879980) Hypothyroidism ( 22493691 27182965) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 30054594) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricle diastolic internal dimension ( 28394258) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 30226566 33532862) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 24026423 27863252 29403010 32888494 33545615) Platelet distribution width ( 27863252) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Reaction time ( 29844566) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Reticulocyte fraction of red cells ( 27863252) Retinal vascular caliber ( 21060863) Sarcoidosis ( 26051272) Serum alkaline phosphatase levels ( 33547301) Serum total protein levels ( 29403010) Sjögren's syndrome ( 24097067) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469 33272962) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Total cholesterol levels ( 30275531) Urate levels ( 23263486 31578528) Vitiligo ( 27723757) White blood cell count ( 32888494)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Adverse response to inhaled corticosteroid treatment x age interaction in asthma ( 32119686) Age at first sexual intercourse ( 34211149) Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 25085501) Alzheimer's disease ( 33074286) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Brain glucose metabolism (fluorodeoxyglucose uptake) ( 30596066) Brain volume in infants (cerebrospinal fluid) ( 28763065) Cataracts ( 34127677) Cerebellum white matter volume ( 31530798) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive decline rate in late mild cognitive impairment ( 26252872) Depression ( 33859377 29700475) Evening vs. morning chronotype (sMEQ score) ( 32579418) Extraversion ( 27918536) Feeling worry ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Glaucoma ( 25027321) HDL cholesterol levels in HIV infection ( 33109212) High myopia ( 31816047) Hydrolysed wheat protein allergy ( 31301374) Hyperopia ( 25233373) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intelligence (MTAG) ( 29326435) Intracranial aneurysm ( 29531279) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Major depressive disorder ( 29728651 27479909) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 31628463) Myopia ( 27182965 25233373) Neurociticism ( 29500382) Neurofibrillary tangles ( 31497858) Neuroticism ( 29255261) Nickel levels ( 26025379) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity (extreme) ( 31852448) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) Pit-and-Fissure caries ( 24556642) Refractive astigmatism ( 30306274) Refractive error ( 23396134 32231278 23474815) Renal cell carcinoma ( 31231134) Rheumatoid arthritis ( 30423114) Severe insulin-resistant type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemising ( 31508503) Systolic blood pressure ( 30224653) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483) tricyclic pyrone compound response (IC50) ( 33610756) Triglyceride levels ( 34074324) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 30130595) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		23 interacting genes: ACTN1 ACTN2 ATXN1 BAG6 BIN1 CEBPA CHGB GFI1B GOLGA6L5P IDH3B KIFBP LCP1 MIR128-1 MIR34B MIR7-1 NCOA4 PABPC1 PLS3 POLR1H RBFOX1 SH3GL2 SH3GL3 TDRD7	49 interacting genes: AGR2 ALG13 ARID5A ATN1 ATXN1 ATXN1L ATXN2 BHLHE40 C1orf94 CELF3 CRX DAB1 DAZAP2 DMRTB1 DVL2 FAM168A GCA HNRNPF HSFX1 HSFY1 HYPK KIFAP3 LASP1 LZTS2 MAGED1 NOC2L NUMBL P4HA3 PCBP4 POGZ PRR20A PRRC2A PSMF1 QKI RBFOX2 RBFOX3 RBM24 RBM47 RBPMS RBPMS2 RHOXF2 SIRPB1 SNRPN SPMIP9 STRBP TNIP1 TOLLIP UBL3 VENTX
Entrez ID		6311	54715
HPRD ID		03307	16091
Ensembl ID		ENSG00000204842	ENSG00000078328
Uniprot IDs		A0A5F9ZI57 F8VQP2 Q2M2R5 Q99700 V9GY86	A0A6Q8PH77 A0A804HJM2 A0A804HKG7 B7Z1U7 F8VZG9 Q59HD3 Q9NWB1 X5D7T5 X5DNY3 X5DP44
PDB IDs		3KTR	2ERR 2N82 4ZKA 7VRL
Enriched GO Terms of Interacting Partners?		Actin Filament Network Formation Actin Filament Binding Actin Filament Actin Filament Bundle Organization Actin Cytoskeleton Organization Actin Filament Bundle Assembly Actin Filament Bundle Regulatory NcRNA-mediated Gene Silencing Actin Filament-based Process Cytoskeleton Organization Pseudopodium Negative Regulation Of Transport Postsynaptic Density, Intracellular Component Postsynaptic Actin Cytoskeleton Organization Identical Protein Binding Postsynaptic Cytoskeleton Organization Poly(U) RNA Binding Positive Regulation Of RNA Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process Actin Cytoskeleton Organelle Organization Focal Adhesion Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Integrin Binding Glutamatergic Synapse Regulation Of Gene Expression Z Disc Cell-substrate Junction Assembly Regulation Of Transport Negative Regulation Of Potassium Ion Transport Actin Filament Uncapping Regulation Of Vesicle-mediated Transport GTPase Binding Synaptic Vesicle Endocytosis Lipid Tube Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Nuclear Matrix Positive Regulation Of Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Structural Constituent Of Presynaptic Actin Cytoskeleton Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Positive Regulation Of MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Negative Regulation Of Lipoprotein Transport MiRNA-mediated Gene Silencing By MRNA Destabilization	Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process MRNA Binding RNA Binding Nucleic Acid Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Cytoplasmic Stress Granule RNA Splicing Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Processing POZ Domain Binding MRNA 3'-UTR Binding MRNA CDS Binding Cytoplasm Regulation Of Metabolic Process Stress Granule Assembly Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Processing Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability MRNA Metabolic Process Pre-mRNA Intronic Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process MRNA Stabilization DNA Binding Pre-mRNA Binding Protein Binding Transcription Coactivator Activity Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nervous System Development
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