ATXN2 and LCP1

Number of citations of the paper that reports this interaction (PMID 16115810)
21

Data Source:
HPRD (two hybrid, in vivo)

		ATXN2	LCP1
Gene Name		ataxin 2	lymphocyte cytosolic protein 1 (L-plastin)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Polysome Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm	Stress Fiber Ruffle Phagocytic Cup Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Filopodium Actin Filament Bundle Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Epidermal Growth Factor Receptor Binding Protein Binding Protein C-terminus Binding Poly(A) RNA Binding	Actin Binding Calcium Ion Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Receptor Internalization Regulation Of Translation RNA Metabolic Process Cerebellar Purkinje Cell Differentiation Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly Negative Regulation Of Multicellular Organism Growth Neuron Projection Morphogenesis Homeostasis Of Number Of Cells RNA Transport Neuromuscular Process	T Cell Activation Involved In Immune Response Protein Kinase A Signaling Cell Migration Organ Regeneration Regulation Of Intracellular Protein Transport Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly
Pathways
Drugs
Diseases
GWAS		Beta-2 microglubulin plasma levels ( 23417110) Blood pressure ( 21909110) Celiac disease ( 18311140) Chronic kidney disease ( 20383146) Diastolic blood pressure ( 19430483) Hematocrit ( 19862010) Hypothyroidism ( 22493691) Red blood cell traits ( 23222517) Retinal vascular caliber ( 21060863) Urate levels ( 23263486)	Non-alcoholic fatty liver disease histology (other) ( 23213074)
Protein-Protein Interactions		19 interactors: ACTN1 ACTN2 ATXN1 BAG6 BIN1 CHGB GFI1B GOLGA6L5P IDH3B KIAA1279 LCP1 NCOA4 PABPC1 PLS3 RBFOX1 SH3GL2 SH3GL3 TDRD7 ZNRD1	5 interactors: AIF1 ATXN2 CNN3 GCA PRKACA
Entrez ID		6311	3936
HPRD ID		03307	01082
Ensembl ID		ENSG00000204842	ENSG00000136167
Uniprot IDs		Q99700	P13796
PDB IDs		3KTR	2D85
Enriched GO Terms of Interacting Partners?		System Development Multicellular Organismal Development Anatomical Structure Development Focal Adhesion Assembly Developmental Process Adherens Junction Assembly Cell-substrate Junction Assembly Actin Filament Bundle Assembly Regulation Of Metabolic Process Platelet Degranulation Lipid Tube Assembly Adherens Junction Organization	Positive Regulation Of Muscle Hyperplasia Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Chemotaxis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Behavior Regulation Of Chemotaxis Histone H3-T6 Phosphorylation Negative Regulation Of Smooth Muscle Cell Chemotaxis Membrane Organization Regulation Of Behavior Positive Regulation Of Smooth Muscle Cell Chemotaxis Cellular Response To Morphine Positive Regulation Of Cell Cycle Process Cellular Response To Isoquinoline Alkaloid Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Cell Cycle Organelle Organization Positive Regulation Of Cell Migration Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Negative Regulation Of Receptor Internalization Regulation Of Tight Junction Assembly Cytoplasmic MRNA Processing Body Assembly Positive Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Glucose Import Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Response To Parathyroid Hormone Negative Regulation Of Transport Cellular Response To Organic Cyclic Compound Phagocytosis, Engulfment Positive Regulation Of Protein Export From Nucleus Microglial Cell Activation Regulation Of Mitotic Cell Cycle Regulation Of Monocyte Chemotaxis Cerebellar Purkinje Cell Differentiation Cell Communication By Electrical Coupling Cellular Response To Hydroperoxide Activation Of Protein Kinase A Activity Stress Granule Assembly
Tagcloud ?		accumulations als amyotrophic basophilic c9orf72 causative cohorts colocalization cord expansion expansions fused ggggcc granules hexanucleotide highlights inclusions indicative motor neuron pabp paralysis polyglutamine proteomic repeat sarcoma spinal tdp transactive	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		accumulations als amyotrophic basophilic c9orf72 causative cohorts colocalization cord expansion expansions fused ggggcc granules hexanucleotide highlights inclusions indicative motor neuron pabp paralysis polyglutamine proteomic repeat sarcoma spinal tdp transactive	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?