IMPA1

Gene Name		inositol(myo)-1(or 4)-monophosphatase 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Inositol Monophosphate 1-phosphatase Activity Manganese Ion Binding Lithium Ion Binding Identical Protein Binding Protein Homodimerization Activity Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity Inositol Monophosphate Phosphatase Activity
	Biological Process	Inositol Biosynthetic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation
Pathways		Synthesis of IP2, IP, and Ins in the cytosol Inositol phosphate metabolism
Drugs		Lithium L-Myo-Inositol-1-Phosphate
Diseases
GWAS		Ovarian cancer ( 23535730)
Protein-protein Interactions		4 interactors: CALB1 IMPA2 NXF1 S100B
Entrez ID		3612
HPRD ID		03641
Ensembl ID		ENSG00000133731
Uniprot IDs		P29218
PDB IDs		1AWB 1IMA 1IMB 1IMC 1IMD 1IME 1IMF 2HHM 4AS4
Enriched GO Terms of Interacting Partners?		Memory Metanephric Connecting Tubule Development Regulation Of Synaptic Plasticity Negative Regulation Of Skeletal Muscle Cell Differentiation Metanephric Part Of Ureteric Bud Development Learning Or Memory Cognition Metanephric Distal Convoluted Tubule Development Regulation Of Synaptic Transmission Metanephric Distal Tubule Development Inositol Biosynthetic Process Poly(A)+ MRNA Export From Nucleus Response To Methylmercury Metanephric Collecting Duct Development Distal Tubule Development Inositol Phosphate Dephosphorylation Phosphorylated Carbohydrate Dephosphorylation Single-organism Behavior Collecting Duct Development Short-term Memory Metanephric Nephron Tubule Development Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Development Behavior Inositol Metabolic Process Retina Layer Formation Metanephric Epithelium Development Metanephros Morphogenesis Astrocyte Differentiation Long-term Memory Negative Regulation Of Striated Muscle Tissue Development Long-term Synaptic Potentiation Inositol Phosphate Metabolic Process Negative Regulation Of Muscle Organ Development Alcohol Catabolic Process Neural Retina Development Retina Morphogenesis In Camera-type Eye Regulation Of Neuronal Synaptic Plasticity MRNA Export From Nucleus Regulation Of Skeletal Muscle Tissue Development
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