ANXA2 and PLAT

Number of citations of the paper that reports this interaction (PubMedID 11978811)
43

Data Source:
HPRD (in vitro, in vivo)

		ANXA2	PLAT
Description		annexin A2	plasminogen activator, tissue type
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Surface Vesicle Membrane Membrane Basolateral Plasma Membrane Nuclear Matrix Midbody Extracellular Matrix Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Membrane Raft Extracellular Exosome RNA Polymerase II Transcription Regulator Complex Plasma Membrane Protein Complex AnxA2-p11 Complex PCSK9-AnxA2 Complex	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Extracellular Exosome Serine Protease Inhibitor Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Phosphatidylserine Binding Protease Binding RNA Binding Phospholipase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Identical Protein Binding S100 Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Phosphoprotein Binding
	Biological Process	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Negative Regulation Of Receptor Internalization Vesicle Budding From Membrane Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Plasminogen Activation Response To Activity Collagen Fibril Organization Lung Development Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis MRNA Transcription By RNA Polymerase II Positive Regulation Of Vacuole Organization Positive Regulation Of Exocytosis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cell-cell Adhesion Epithelial Cell Apoptotic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Plasma Membrane Repair	Response To Hypoxia Proteolysis Blood Coagulation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Zymogen Activation Plasminogen Activation Protein Modification Process Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Pathways		Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells	Signaling by PDGF Dissolution of Fibrin Clot
Drugs		Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol	Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)	Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)
Interacting Genes		51 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF EIF4ENIF1 FNDC3B FOXP1 GRB2 HMGA1 LGALS13 LINC00941 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB1 PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMN1 SNCA SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 WEE2-AS1 YWHAQ ZBTB4	28 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SNCA SPARC VDAC1
Entrez ID		302	5327
HPRD ID		01061	01419
Ensembl ID		ENSG00000182718	ENSG00000104368
Uniprot IDs		A0A024R5Z7 H0YL33 P07355	B4DN26 P00750
PDB IDs		1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY 7DTO 7EQ7 7NMI 7P70 7P71 7P72 7P73 7P74 7PC3 7PC4 7PC5 7PC7 7PC8 7PC9 7PCB 7QQL 7QQM 7QQN 7ZVN 7ZVX 8AEL	1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Extracellular Exosome Regulation Of Cell Population Proliferation Enzyme Binding Regulation Of Locomotion Negative Regulation Of Wound Healing Regulation Of Transport Nuclear Telomere Cap Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Positive Regulation Of Metabolic Process Negative Regulation Of Fibrinolysis Leukocyte Activation Regulation Of Cell Motility Positive Regulation Of Immune System Process Histone H3T6 Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Cell Junction Assembly Regulation Of Fibrinolysis Negative Regulation Of Coagulation Regulation Of Cell Activation Positive Regulation Of Organelle Organization Regulation Of Immune Response Cell Activation Regulation Of Cell Adhesion Regulation Of MAPK Cascade Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Immune Response Phosphatidylcholine Lysophospholipase Activity Extracellular Matrix Identical Protein Binding Macrophage Activation Positive Regulation Of Cell Migration Regulation Of Endocytosis Negative Regulation Of Cell-substrate Adhesion Telomere Maintenance Via Telomerase Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myeloid Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Focal Adhesion Assembly Trans-synaptic Signaling By BDNF Protein Kinase C Signaling	Fibrinolysis Extracellular Space Regulation Of Locomotion Regulation Of Cell Migration Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Extracellular Region Positive Regulation Of Locomotion Endoplasmic Reticulum Lumen Negative Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Wound Healing Serine-type Endopeptidase Inhibitor Activity Regulation Of Plasminogen Activation Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Platelet Alpha Granule Regulation Of Cell Adhesion Cell Surface Regulation Of Response To Wounding Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Maturation Positive Regulation Of Signaling Extracellular Exosome Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Endocytosis Basement Membrane Plasma Membrane Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Positive Regulation Of Cell Communication Blood Coagulation Positive Regulation Of Cellular Component Organization Coagulation Protease Binding Hemostasis Peptidase Inhibitor Activity Regulation Of Endocytosis Negative Regulation Of Multicellular Organismal Process Calcium Ion Binding
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