RYK and EPHB2

Number of citations of the paper that reports this interaction (PMID 11956217)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RYK	EPHB2
Gene Name		receptor-like tyrosine kinase	EPH receptor B2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding	Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Axon Guidance Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Corpus Callosum Development Neuron Differentiation Neuron Projection Development Positive Regulation Of MAPK Cascade	Angiogenesis Urogenital System Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis Commissural Neuron Axon Guidance
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling L1CAM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EPHB2 EPHB3 FZD8 WNT1 WNT3A	36 interactors: ABL1 ABL2 ACP1 AQP1 ARHGEF6 BCL2 CRK EFNA5 EFNB1 EFNB2 ERF FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MLLT4 MMP2 MMP9 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 VAV2 VEGFA YES1
Entrez ID		6259	2048
HPRD ID		02751	02997
Ensembl ID		ENSG00000163785	ENSG00000133216
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	P29323
PDB IDs			1B4F 1F0M 2QBX
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Positive Regulation Of Dermatome Development Anatomical Structure Formation Involved In Morphogenesis Neuron Differentiation Forebrain Development Canonical Wnt Signaling Pathway Inner Ear Morphogenesis Regulation Of Cell Projection Organization Palate Development Generation Of Neurons Ear Morphogenesis Neurogenesis Dendritic Spine Morphogenesis Regulation Of Axonogenesis Spinal Cord Association Neuron Differentiation Immune System Development Inner Ear Development Corpus Callosum Development Dendritic Spine Development Brain Development Head Development Retinal Ganglion Cell Axon Guidance Dendritic Spine Organization Dorsal Spinal Cord Development Nervous System Development Cardiovascular System Development Ear Development Axonal Fasciculation Anatomical Structure Morphogenesis Central Nervous System Development Wnt Signaling Pathway Telencephalon Development Positive Regulation Of Embryonic Development Positive Regulation Of Synapse Assembly Positive Regulation Of Cellular Component Biogenesis Neuron Recognition Embryonic Organ Morphogenesis Homotypic Cell-cell Adhesion Angiogenesis Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Receptor Activity Cell Adhesion Organ Development Regulation Of Cell-cell Adhesion Regulation Of Signaling Regulation Of Neuron Projection Development Urogenital System Development Cell Surface Receptor Signaling Pathway Axon Guidance Blood Vessel Morphogenesis	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ephrin Receptor Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Neuron Development Cell Projection Morphogenesis Cell Projection Organization Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Differentiation Cell Morphogenesis Response To External Stimulus Generation Of Neurons Cell Development Neurogenesis Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Signaling Cell Communication Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction System Development Regulation Of Signaling Cellular Response To Stimulus Anatomical Structure Development Multicellular Organismal Development Developmental Process Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cell Migration Regulation Of Phosphorus Metabolic Process
Tagcloud ?		activate corpuscles culture endothelium epithelial fgf hassall immunohistochemistry jak1 jak2 kinases latter least localisation medulla medullary pdgf receive signals situ substrates throughout thymic thymocytes thymus tyrosine vascular weak	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Difference) ?		activate corpuscles culture endothelium epithelial fgf hassall immunohistochemistry jak1 jak2 kinases latter least localisation medulla medullary pdgf receive signals situ substrates throughout thymic thymocytes thymus tyrosine vascular weak	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Intersection) ?