RYK and EPHB3

Number of citations of the paper that reports this interaction (PMID 11956217)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RYK	EPHB3
Gene Name		receptor-like tyrosine kinase	EPH receptor B3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding	Ephrin Receptor Activity ATP Binding Axon Guidance Receptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Axon Guidance Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Corpus Callosum Development Neuron Differentiation Neuron Projection Development Positive Regulation Of MAPK Cascade	Angiogenesis Urogenital System Development Axon Guidance Axonal Fasciculation Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Rac GTPase Activity Substrate Adhesion-dependent Cell Spreading Regulation Of Cdc42 GTPase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Thymus Development Digestive Tract Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EPHB2 EPHB3 FZD8 WNT1 WNT3A	9 interactors: CRK EFNB3 FYN GBE1 LNX1 MLLT4 NFRKB RASA1 RYK
Entrez ID		6259	2049
HPRD ID		02751	03502
Ensembl ID		ENSG00000163785	ENSG00000182580
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	P54753
PDB IDs			3P1I
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Positive Regulation Of Dermatome Development Anatomical Structure Formation Involved In Morphogenesis Neuron Differentiation Forebrain Development Canonical Wnt Signaling Pathway Inner Ear Morphogenesis Regulation Of Cell Projection Organization Palate Development Generation Of Neurons Ear Morphogenesis Neurogenesis Dendritic Spine Morphogenesis Regulation Of Axonogenesis Spinal Cord Association Neuron Differentiation Immune System Development Inner Ear Development Corpus Callosum Development Dendritic Spine Development Brain Development Head Development Retinal Ganglion Cell Axon Guidance Dendritic Spine Organization Dorsal Spinal Cord Development Nervous System Development Cardiovascular System Development Ear Development Axonal Fasciculation Anatomical Structure Morphogenesis Central Nervous System Development Wnt Signaling Pathway Telencephalon Development Positive Regulation Of Embryonic Development Positive Regulation Of Synapse Assembly Positive Regulation Of Cellular Component Biogenesis Neuron Recognition Embryonic Organ Morphogenesis Homotypic Cell-cell Adhesion Angiogenesis Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Receptor Activity Cell Adhesion Organ Development Regulation Of Cell-cell Adhesion Regulation Of Signaling Regulation Of Neuron Projection Development Urogenital System Development Cell Surface Receptor Signaling Pathway Axon Guidance Blood Vessel Morphogenesis	Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Peptidyl-tyrosine Phosphorylation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Development Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Regulation Of Ras GTPase Activity Regulation Of Cell Shape Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Ras Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Generation Of Neurons Regulation Of Signal Transduction Neurogenesis Regulation Of Small GTPase Mediated Signal Transduction Platelet Activation Negative Regulation Of Neuron Death Axon Choice Point Recognition Establishment Of Endothelial Intestinal Barrier Regulation Of GTPase Activity Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Neuron Apoptotic Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Phagocytosis Cellular Response To Platelet-derived Growth Factor Stimulus
Tagcloud ?		activate corpuscles culture endothelium epithelial fgf hassall immunohistochemistry jak1 jak2 kinases latter least localisation medulla medullary pdgf receive signals situ substrates throughout thymic thymocytes thymus tyrosine vascular weak	ascl2 cdh1 collapse compete corepressor crc demethylase deregulates disabling displaying emt encapsulation engages hdacs incompletely inducers intriguingly invasiveness lsd1 migratory palisading repress roadblock snail1 snail2 stemness tcf7l2 xenotransplants zeb1
Tagcloud (Difference) ?		activate corpuscles culture endothelium epithelial fgf hassall immunohistochemistry jak1 jak2 kinases latter least localisation medulla medullary pdgf receive signals situ substrates throughout thymic thymocytes thymus tyrosine vascular weak	ascl2 cdh1 collapse compete corepressor crc demethylase deregulates disabling displaying emt encapsulation engages hdacs incompletely inducers intriguingly invasiveness lsd1 migratory palisading repress roadblock snail1 snail2 stemness tcf7l2 xenotransplants zeb1
Tagcloud (Intersection) ?