RYK and EPHB3

Number of citations of the paper that reports this interaction (PubMedID 11956217)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RYK	EPHB3
Description		receptor like tyrosine kinase	EPH receptor B3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Receptor Complex Presynaptic Active Zone Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Wnt Receptor Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Axon Guidance Synapse Assembly Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Proliferation In Midbrain Midbrain Dopaminergic Neuron Differentiation	Angiogenesis Urogenital System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Axonal Fasciculation Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Regulation Of GTPase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Thymus Development Digestive Tract Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis
Pathways		TCF dependent signaling in response to WNT PCP/CE pathway	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Systolic blood pressure ( 27841878 28135244)	Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A	14 interacting genes: AFDN CRK EFNB3 ERBB2 FBXO7 FYN GBE1 HPCAL1 HSF2BP LNX1 NFRKB RASA1 RNF186 RYK
Entrez ID		6259	2049
HPRD ID		02751	03502
Ensembl ID		ENSG00000163785	ENSG00000182580
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	P54753
PDB IDs		6TUA	3P1I 3ZFY 5L6O 5L6P
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Adhesion Lymphocyte Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Dermatome Development Wnt-Frizzled-LRP5/6 Complex Leukocyte Activation Cell Proliferation In Midbrain Inner Ear Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Morphogenesis Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Cell Activation Roof Of Mouth Development Protein Dephosphorylation Axon Guidance Receptor Activity Spinal Cord Association Neuron Differentiation Canonical Wnt Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Midbrain Dopaminergic Neuron Differentiation Ephrin Receptor Activity Signaling Receptor Binding Dendritic Spine Development Transmembrane-ephrin Receptor Activity Urogenital System Development Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Process Regulation Of Neuron Projection Development Dendritic Spine Morphogenesis Negative Regulation Of Neurogenesis Regulation Of Nervous System Development Dephosphorylation Phosphoprotein Phosphatase Activity Positive Regulation Of Embryonic Development Regulation Of Axonogenesis Corpus Callosum Development Positive Regulation Of Lymphocyte Proliferation Axonal Fasciculation Neuron Projection Fasciculation Positive Regulation Of Mononuclear Cell Proliferation Retinal Ganglion Cell Axon Guidance Axonogenesis Regulation Of Synapse Assembly Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Central Nervous System Projection Neuron Axonogenesis Negative Regulation Of Cell Projection Organization Negative Regulation Of Multicellular Organismal Process Dendritic Spine Organization	Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Neuron Projection Guidance Axon Guidance Positive Regulation Of Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Reelin-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Protein Tyrosine Kinase Activity Regulation Of Cell Shape Positive Regulation Of Protein Targeting To Membrane Regulation Of Developmental Process Signaling Receptor Binding Regulation Of Protein Targeting To Membrane Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Projection Organization Phosphotyrosine Residue Binding Negative Regulation Of Immune System Process Cellular Developmental Process Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Developmental Process T Cell Costimulation Regulation Of Multicellular Organismal Development Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Negative Regulation Of Axonogenesis Hippocampal Mossy Fiber To CA3 Synapse Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Cell Junction Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen 1,4-alpha-glucan Branching Enzyme Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona
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