RYK and WNT1

Number of citations of the paper that reports this interaction (PMID 15454084)
100

Data Source:
HPRD (in vitro)

		RYK	WNT1
Gene Name		receptor-like tyrosine kinase	wingless-type MMTV integration site family, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding	Frizzled Binding Cytokine Activity Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Receptor Agonist Activity
	Biological Process	Protein Phosphorylation Signal Transduction Axon Guidance Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Corpus Callosum Development Neuron Differentiation Neuron Projection Development Positive Regulation Of MAPK Cascade	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Cell-cell Signaling Myoblast Fusion Positive Regulation Of Cell Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Midbrain Development Organ Regeneration T Cell Differentiation In Thymus Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Neuron Fate Determination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Aging Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EPHB2 EPHB3 FZD8 WNT1 WNT3A	9 interactors: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A
Entrez ID		6259	7471
HPRD ID		02751	01276
Ensembl ID		ENSG00000163785
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	P04628
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Positive Regulation Of Dermatome Development Anatomical Structure Formation Involved In Morphogenesis Neuron Differentiation Forebrain Development Canonical Wnt Signaling Pathway Inner Ear Morphogenesis Regulation Of Cell Projection Organization Palate Development Generation Of Neurons Ear Morphogenesis Neurogenesis Dendritic Spine Morphogenesis Regulation Of Axonogenesis Spinal Cord Association Neuron Differentiation Immune System Development Inner Ear Development Corpus Callosum Development Dendritic Spine Development Brain Development Head Development Retinal Ganglion Cell Axon Guidance Dendritic Spine Organization Dorsal Spinal Cord Development Nervous System Development Cardiovascular System Development Ear Development Axonal Fasciculation Anatomical Structure Morphogenesis Central Nervous System Development Wnt Signaling Pathway Telencephalon Development Positive Regulation Of Embryonic Development Positive Regulation Of Synapse Assembly Positive Regulation Of Cellular Component Biogenesis Neuron Recognition Embryonic Organ Morphogenesis Homotypic Cell-cell Adhesion Angiogenesis Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Receptor Activity Cell Adhesion Organ Development Regulation Of Cell-cell Adhesion Regulation Of Signaling Regulation Of Neuron Projection Development Urogenital System Development Cell Surface Receptor Signaling Pathway Axon Guidance Blood Vessel Morphogenesis	Wnt Signaling Pathway Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Convergent Extension Anterior/posterior Pattern Specification Somitogenesis Stem Cell Proliferation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Somite Development Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Post-anal Tail Morphogenesis Regulation Of Phosphorylation Immune System Development Regulation Of Embryonic Development Segmentation Regulation Of Protein Kinase Activity Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Kinase Activity Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Developmental Growth Involved In Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Tube Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Pattern Specification Process Regulation Of Organ Morphogenesis Regulation Of Bone Remodeling Morphogenesis Of An Epithelium Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Organ Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Ossification Regulation Of Protein Phosphorylation Mesenchyme Development Neural Crest Formation
Tagcloud ?		activate corpuscles culture endothelium epithelial fgf hassall immunohistochemistry jak1 jak2 kinases latter least localisation medulla medullary pdgf receive signals situ substrates throughout thymic thymocytes thymus tyrosine vascular weak	access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would
Tagcloud (Difference) ?		activate corpuscles culture endothelium epithelial fgf hassall immunohistochemistry jak1 jak2 kinases latter least localisation medulla medullary pdgf receive signals situ substrates throughout thymic thymocytes thymus tyrosine vascular weak	access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would
Tagcloud (Intersection) ?