RYK and FZD8

Number of citations of the paper that reports this interaction (PubMedID 15454084)
0

Data Source:
HPRD (in vivo)

		RYK	FZD8
Description		receptor like tyrosine kinase	frizzled class receptor 8
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Receptor Complex Presynaptic Active Zone Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Golgi Apparatus Plasma Membrane Membrane Neuronal Dense Core Vesicle Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Wnt Receptor Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Axon Guidance Synapse Assembly Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Proliferation In Midbrain Midbrain Dopaminergic Neuron Differentiation	Angiogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT PCP/CE pathway	Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Systolic blood pressure ( 27841878 28135244)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Interacting Genes		8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A	5 interacting genes: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		6259	8325
HPRD ID		02751	05852
Ensembl ID		ENSG00000163785	ENSG00000177283
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	Q9H461
PDB IDs		6TUA	5UN5 5UN6 6NDZ 8X0T
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Adhesion Lymphocyte Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Dermatome Development Wnt-Frizzled-LRP5/6 Complex Leukocyte Activation Cell Proliferation In Midbrain Inner Ear Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Morphogenesis Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Cell Activation Roof Of Mouth Development Protein Dephosphorylation Axon Guidance Receptor Activity Spinal Cord Association Neuron Differentiation Canonical Wnt Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Midbrain Dopaminergic Neuron Differentiation Ephrin Receptor Activity Signaling Receptor Binding Dendritic Spine Development Transmembrane-ephrin Receptor Activity Urogenital System Development Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Process Regulation Of Neuron Projection Development Dendritic Spine Morphogenesis Negative Regulation Of Neurogenesis Regulation Of Nervous System Development Dephosphorylation Phosphoprotein Phosphatase Activity Positive Regulation Of Embryonic Development Regulation Of Axonogenesis Corpus Callosum Development Positive Regulation Of Lymphocyte Proliferation Axonal Fasciculation Neuron Projection Fasciculation Positive Regulation Of Mononuclear Cell Proliferation Retinal Ganglion Cell Axon Guidance Axonogenesis Regulation Of Synapse Assembly Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Central Nervous System Projection Neuron Axonogenesis Negative Regulation Of Cell Projection Organization Negative Regulation Of Multicellular Organismal Process Dendritic Spine Organization	Midbrain Dopaminergic Neuron Differentiation Wnt Receptor Activity Canonical Wnt Signaling Pathway Wnt-protein Binding Frizzled Binding Dopaminergic Neuron Differentiation Wnt-Frizzled-LRP5/6 Complex Coreceptor Activity Wnt Signaling Pathway Toxin Transmembrane Transporter Activity Wnt Signalosome Central Nervous System Neuron Differentiation Midbrain Development Response To Peptide Hormone Neuron Differentiation Bone Development Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Anion Channel Activity Cell-cell Signaling Involved In Mammary Gland Development Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of Cell Proliferation In Midbrain Central Nervous System Morphogenesis Diencephalon Development Neurogenesis Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Regulation Of Fat Cell Differentiation Cell-cell Signaling Signaling Response To Hormone Morphogenesis Of A Branching Epithelium Norrin Signaling Pathway Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Communication Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Mesodermal Cell Migration Apoptotic Process Involved In Blood Vessel Morphogenesis Negative Regulation Of Cell Differentiation Extracellular Matrix-cell Signaling Cell Proliferation In Midbrain Retinal Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier Chemorepulsion Of Axon
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