RYK and WNT3A

Number of citations of the paper that reports this interaction (PubMedID 15454084)
0

Data Source:
HPRD (in vitro)

		RYK	WNT3A
Description		receptor like tyrosine kinase	Wnt family member 3A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Receptor Complex Presynaptic Active Zone Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Early Endosome Membrane Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Wnt Receptor Activity	Transcription Coactivator Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Co-receptor Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Axon Guidance Synapse Assembly Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Proliferation In Midbrain Midbrain Dopaminergic Neuron Differentiation	Osteoblast Differentiation In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Heart Looping Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Determination Of Left/right Symmetry Axonogenesis Axon Guidance Mesoderm Development Heart Development Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification COP9 Signalosome Assembly Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Neurogenesis Hemopoiesis Platelet Activation Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Synaptic Vesicle Recycling B Cell Proliferation Inner Ear Morphogenesis Cell Fate Commitment Fat Cell Differentiation Myoblast Differentiation Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Division Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Animal Organ Development Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Canonical Wnt Signaling Pathway Cardiac Muscle Cell Fate Commitment Positive Regulation Of Dermatome Development Secondary Palate Development Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Presynapse Assembly Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Regulation Of Postsynapse To Nucleus Signaling Pathway Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation Regulation Of RNA Biosynthetic Process
Pathways		TCF dependent signaling in response to WNT PCP/CE pathway	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants Formation of paraxial mesoderm Formation of the posterior neural plate Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Systolic blood pressure ( 27841878 28135244)	Alcohol-related hepatocellular carcinoma ( 34902334) Birth weight ( 31043758) Diastolic blood pressure ( 28135244) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A	11 interacting genes: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2
Entrez ID		6259	89780
HPRD ID		02751	05897
Ensembl ID		ENSG00000163785	ENSG00000154342
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	P56704
PDB IDs		6TUA	7DRT 7URD 7URE 8TZR
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Adhesion Lymphocyte Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Dermatome Development Wnt-Frizzled-LRP5/6 Complex Leukocyte Activation Cell Proliferation In Midbrain Inner Ear Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Projection Morphogenesis Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Cell Activation Roof Of Mouth Development Protein Dephosphorylation Axon Guidance Receptor Activity Spinal Cord Association Neuron Differentiation Canonical Wnt Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Midbrain Dopaminergic Neuron Differentiation Ephrin Receptor Activity Signaling Receptor Binding Dendritic Spine Development Transmembrane-ephrin Receptor Activity Urogenital System Development Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Process Regulation Of Neuron Projection Development Dendritic Spine Morphogenesis Negative Regulation Of Neurogenesis Regulation Of Nervous System Development Dephosphorylation Phosphoprotein Phosphatase Activity Positive Regulation Of Embryonic Development Regulation Of Axonogenesis Corpus Callosum Development Positive Regulation Of Lymphocyte Proliferation Axonal Fasciculation Neuron Projection Fasciculation Positive Regulation Of Mononuclear Cell Proliferation Retinal Ganglion Cell Axon Guidance Axonogenesis Regulation Of Synapse Assembly Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Central Nervous System Projection Neuron Axonogenesis Negative Regulation Of Cell Projection Organization Negative Regulation Of Multicellular Organismal Process Dendritic Spine Organization	Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Wnt Signaling Pathway Wnt-protein Binding Central Nervous System Neuron Differentiation Cell-cell Signaling Signaling Cell Communication Wnt Signalosome Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Wnt Receptor Activity Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Cellular Component Organization Neuron Differentiation Branching Involved In Ureteric Bud Morphogenesis Glial Cell-neuron Signaling Tissue Morphogenesis Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Signal Transduction Hard Palate Development GMP Kinase Activity Endocytic Vesicle Membrane Neuromuscular Junction Protein Localization To Cell Junction GDP Metabolic Process Juxtaparanode Region Of Axon Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tube Morphogenesis Protein Localization To Membrane Chemical Synaptic Transmission Kinase Binding Cellular Response To Potassium Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Developmental Process Trans-synaptic Signaling Regulation Of BMP Signaling Pathway Neurogenesis
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