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RPS15 and UPF2
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
HPRD
(two hybrid)
RPS15
UPF2
Description
ribosomal protein S15
UPF2 regulator of nonsense mediated mRNA decay
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ribosome
Focal Adhesion
Small Ribosomal Subunit
Membrane
Cytosolic Ribosome
Cytosolic Small Ribosomal Subunit
Synapse
Ribonucleoprotein Complex
Nucleus
Cytoplasm
Cytosol
Exon-exon Junction Complex
Cytoplasmic Ribonucleoprotein Granule
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
MDM2/MDM4 Family Protein Binding
Ubiquitin Ligase Inhibitor Activity
RNA Binding
Protein Binding
Telomeric DNA Binding
Biological Process
Ribosomal Small Subunit Assembly
Ribosomal Small Subunit Export From Nucleus
Osteoblast Differentiation
Cytoplasmic Translation
RRNA Processing
Translation
Ribosomal Small Subunit Biogenesis
Liver Regeneration
Positive Regulation Of Signal Transduction By P53 Class Mediator
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Liver Development
MRNA Export From Nucleus
Animal Organ Regeneration
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
SARS-CoV-1 modulates host translation machinery
SARS-CoV-2 modulates host translation machinery
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Red blood cell count (
32888494
)
Diverticular disease (
30177863
)
Interacting Genes
15 interacting genes:
CDC42
DUX4
ERCC6
G2E3
GSK3A
GSK3B
NAP1L1
PLA2G12A
PTEN
RAPGEF1
RPS4X
SERINC3
TNFAIP3
UBC
UPF2
76 interacting genes:
ABCF2
AGPAT1
AKTIP
ART4
ATP1B3
BLM
CALR
CENPU
CIZ1
COMTD1
CYBA
DCP1B
DCP2
DPF2
E4F1
EIF1
EIF4A1
EIF4G1
ENO1
EXOSC1
EXOSC10
EXOSC4
EXOSC6
EXOSC8
GADD45GIP1
HBZ
HMGA1
HS3ST3A1
HSF2BP
ITGB1
KRT18
LDHA
LSM1
MAP1A
MAP1LC3B
MIF
MRPL40
MTERF3
MTREX
MYB
NDUFA7
NOB1
NOMO1
NOP53
PHB2
PITX1
PUF60
RNPS1
RPL13
RPL5
RPL8
RPS15
RPS25
RPS6
RPS7
RRP7A
RSRC2
SERBP1
SERF2
SMG1
SUMO3
TK1
TNNI2
TOP3B
TUBB2A
TYMS
UPF1
UPF3B
WNK1
XRN1
XRN2
ZBTB48
ZFP36
ZGPAT
ZNF408
ZNF44
Entrez ID
6209
26019
HPRD ID
01613
10405
Ensembl ID
ENSG00000115268
ENSG00000151461
Uniprot IDs
K7ELC2
P62841
Q9HAU5
PDB IDs
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6FEC
6G18
6G4S
6G4W
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBS
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOL
6ZON
6ZP4
6ZUO
6ZV6
6ZVH
6ZVJ
6ZXD
6ZXE
6ZXF
6ZXG
6ZXH
7A09
7K5I
7QP6
7QP7
7R4X
7TQL
7WTT
7WTU
7WTV
7WTW
7WTX
7WTZ
7WU0
7XNX
7XNY
8G5Y
8G60
8G61
8G6J
8GLP
8IFD
8IFE
8JDJ
8JDK
8JDL
8JDM
8K2C
8OZ0
8PJ1
8PJ2
8PJ3
8PJ4
8PJ5
8PJ6
8PPK
8PPL
8QOI
8T4S
8UKB
8XP2
8XP3
8XSX
8XSY
8XSZ
8XXL
8XXM
8XXN
8Y0W
8Y0X
8YOO
8YOP
8ZDB
8ZDC
8ZDD
9BKD
9BLN
9C3H
9G8M
9G8O
1UW4
2WJV
4CEK
4CEM
7NWU
7QG6
Enriched GO Terms of Interacting Partners
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Nervous System Development
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Regulation Of Glycogen (starch) Synthase Activity
Neuron Projection Organization
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
System Development
Cellular Response To Interleukin-3
Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cytoplasm
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Protein Metabolic Process
Cytoplasmic Ribonucleoprotein Granule
Beta-catenin Destruction Complex
Protein Kinase A Catalytic Subunit Binding
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Dendritic Spine Morphogenesis
Membrane Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Protein Modification Process
Tau-protein Kinase Activity
Regulation Of Cell Projection Organization
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Viral Protein Processing
Positive Regulation Of Mitochondrial Membrane Permeability
Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Membrane Permeability
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Dendritic Spine Organization
Negative Regulation Of Organ Growth
Regulation Of Neuron Projection Development
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Glycogen Metabolic Process
Intracellular Signaling Cassette
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Protein Ubiquitination
Neuron Projection Development
Postsynapse Organization
Regulation Of Defense Response To Virus By Host
Tau Protein Binding
Positive Regulation Of Proteolysis
Negative Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of UDP-glucose Catabolic Process
RNA Binding
Nuclear-transcribed MRNA Catabolic Process
RNA Catabolic Process
MRNA Catabolic Process
Nucleobase-containing Compound Catabolic Process
RRNA Metabolic Process
RRNA Processing
Nucleic Acid Metabolic Process
Exosome (RNase Complex)
Nucleus
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
RNA Metabolic Process
Histone MRNA Catabolic Process
Nuclear Exosome (RNase Complex)
Negative Regulation Of Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Nucleolar Exosome (RNase Complex)
Negative Regulation Of Macromolecule Biosynthetic Process
Nuclear MRNA Surveillance
Ribosome
Histone MRNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Cytoplasmic Exosome (RNase Complex)
RNA Exonuclease Activity
Regulation Of Gene Expression
Ribonucleoprotein Complex Biogenesis
Regulation Of Macromolecule Biosynthetic Process
MRNA Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
RNA Processing
Ribosomal Small Subunit Biogenesis
Translation
Regulation Of Macromolecule Metabolic Process
Ribonucleoprotein Complex
Nucleolus
Nucleic Acid Binding
Cytosolic Ribosome
Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
5'-3' RNA Exonuclease Activity
Regulation Of Metabolic Process
Nuclear RNA Surveillance
RRNA Catabolic Process
RNA Surveillance
DNA Metabolic Process
Cytosol
Cytoplasmic Translation
Negative Regulation Of Protein Metabolic Process
Macromolecule Catabolic Process
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