RPS15 and RAPGEF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPS15	RAPGEF1
Description		ribosomal protein S15	Rap guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Focal Adhesion Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Ribonucleoprotein Complex	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane
	Molecular Function	DNA Binding RNA Binding Structural Constituent Of Ribosome Protein Binding MDM2/MDM4 Family Protein Binding Ubiquitin Ligase Inhibitor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Ribosomal Small Subunit Assembly Ribosomal Small Subunit Export From Nucleus Osteoblast Differentiation Cytoplasmic Translation RRNA Processing Translation Ribosomal Small Subunit Biogenesis Liver Regeneration Positive Regulation Of Signal Transduction By P53 Class Mediator	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494)	Cerebrospinal fluid α-synuclein levels ( 29959729) Cutaneous malignant melanoma ( 32341527) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Kidney volume ( 34128465) Nevus count or cutaneous melanoma ( 32341527) Optic disc size ( 31809533)
Interacting Genes		15 interacting genes: CDC42 DUX4 ERCC6 G2E3 GSK3A GSK3B NAP1L1 PLA2G12A PTEN RAPGEF1 RPS4X SERINC3 TNFAIP3 UBC UPF2	19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		6209	2889
HPRD ID		01613	02627
Ensembl ID		ENSG00000115268	ENSG00000107263
Uniprot IDs		K7ELC2 P62841	A0A1S5UYZ7 A0A804HL87 Q13905
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7R4X 7TQL 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	5L23
Enriched GO Terms of Interacting Partners?		Nervous System Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Glycogen (starch) Synthase Activity Neuron Projection Organization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway System Development Cellular Response To Interleukin-3 Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cytoplasm Regulation Of Cell-substrate Adhesion Positive Regulation Of Protein Metabolic Process Cytoplasmic Ribonucleoprotein Granule Beta-catenin Destruction Complex Protein Kinase A Catalytic Subunit Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Dendritic Spine Morphogenesis Membrane Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Protein Modification Process Tau-protein Kinase Activity Regulation Of Cell Projection Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Peptidyl-serine Phosphorylation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Membrane Permeability Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Dendritic Spine Organization Negative Regulation Of Organ Growth Regulation Of Neuron Projection Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Metabolic Process Intracellular Signaling Cassette Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Ubiquitination Neuron Projection Development Postsynapse Organization Regulation Of Defense Response To Virus By Host Tau Protein Binding Positive Regulation Of Proteolysis Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Population Proliferation Negative Regulation Of UDP-glucose Catabolic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Small GTPase-mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament-based Process Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway GDP Binding Regulation Of Protein Localization To Membrane Regulation Of Cell Migration Response To Growth Factor Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Locomotion Positive Regulation Of Signaling Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Rap Protein Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Focal Adhesion Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Lymphocyte Migration Cytosol Cell Motility GTPase Activity
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