MRPL12 and SEPTIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRPL12	SEPTIN1
Description		mitochondrial ribosomal protein L12	septin 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Cytoplasm Centrosome Cytoskeleton Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Midbody Septin Complex Cell Division Site Meiotic Spindle
	Molecular Function	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Mitochondrial Transcription Translation Mitochondrial Translation Positive Regulation Of DNA-templated Transcription	Spindle Assembly Involved In Female Meiosis Intracellular Protein Localization Regulation Of Exocytosis Cell Division Meiotic Metaphase Chromosome Alignment Cytoskeleton-dependent Cytokinesis
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial protein degradation Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS		LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Refractive error ( 32231278) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		25 interacting genes: CBX3 COX6A2 DRC8 EFEMP2 EXOC3L2 FBLN1 KRTAP10-1 MAPRE3 MICOS10-NBL1 MORF4L1 MORF4L2 NBL1 NTAQ1 NTM OLIG1 POLR1D PPP1R16A RARG SAT1 SEPTIN1 TMEM51 TRIM59 TXNDC9 UBC ZNF76	24 interacting genes: AMOT APP AURKB DDIT4L DNAJB13 GORASP2 GPSM1 HSF2BP LNX1 MID2 MRPL12 NIF3L1 PICK1 PIH1D1 SDCBP SEPTIN11 SEPTIN3 SEPTIN5 SEPTIN6 SEPTIN9 TEX11 TOLLIP UBC UBE2I
Entrez ID		6182	1731
HPRD ID		03849	15324
Ensembl ID		ENSG00000262814	ENSG00000180096
Uniprot IDs		P52815	J3KNL2 Q8WYJ6
PDB IDs		6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7L08 7L20 7O9K 7O9M 7OG4 7PO2 7PO4 7QI4 7QI5 7QI6 8ANY 8OIR 8OIT	6WBE
Enriched GO Terms of Interacting Partners?		Elastic Fiber Determination Of Dorsal Identity Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction BMP Binding Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Stem Cell Proliferation NuA4 Histone Acetyltransferase Complex	Septin Ring Septin Complex Cell Division Site Cytoskeleton-dependent Cytokinesis Molecular Adaptor Activity Microtubule Cytoskeleton Cell Division Cytoplasm GTPase Activity Intracellular Protein Localization Cytoskeleton GTP Binding Regulation Of Receptor Internalization Stress Fiber Synaptonemal Complex Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization Synaptic Vesicle Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Frizzled Binding Interleukin-5 Receptor Complex SUMO Conjugating Enzyme Activity Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Phosphoprotein Binding Septin Collar Meiotic Gene Conversion
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