MRPL12 and MORF4L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRPL12	MORF4L2
Description		mitochondrial ribosomal protein L12	mortality factor 4 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Nucleosome Nucleus Nucleoplasm Nucleolus Plasma Membrane NuA4 Histone Acetyltransferase Complex
	Molecular Function	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding
	Biological Process	Mitochondrial Transcription Translation Mitochondrial Translation Positive Regulation Of DNA-templated Transcription	DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial protein degradation Mitochondrial ribosome-associated quality control	HATs acetylate histones
Drugs
Diseases
GWAS		LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Refractive error ( 32231278) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494)
Interacting Genes		25 interacting genes: CBX3 COX6A2 DRC8 EFEMP2 EXOC3L2 FBLN1 KRTAP10-1 MAPRE3 MICOS10-NBL1 MORF4L1 MORF4L2 NBL1 NTAQ1 NTM OLIG1 POLR1D PPP1R16A RARG SAT1 SEPTIN1 TMEM51 TRIM59 TXNDC9 UBC ZNF76	54 interacting genes: AMOTL2 ARID3A BCL11A BEND7 BEX5 CAMK2B CDR2 CEP55 DDIT4L DISC1 DSCAM EVI5 FAM9B FBXO16 GOLGA2 GPBP1 GRAMD2B HDAC1 HMBOX1 HOMEZ HUNK IKZF1 KCTD1 KLHL3 L3MBTL3 LUZP4 LZTS2 MEOX2 MRFAP1 MRGBP MRPL12 NAB2 PHC2 PIBF1 PICK1 PNMA2 POU6F2 RB1 REL SIN3A SYN3 THAP1 TLE1 TLE5 TNIP1 TNNT2 TRIM41 TSN ZBTB10 ZBTB14 ZBTB26 ZBTB43 ZBTB7B ZNF48
Entrez ID		6182	9643
HPRD ID		03849	02326
Ensembl ID		ENSG00000262814	ENSG00000123562
Uniprot IDs		P52815	Q15014
PDB IDs		6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7L08 7L20 7O9K 7O9M 7OG4 7PO2 7PO4 7QI4 7QI5 7QI6 8ANY 8OIR 8OIT
Enriched GO Terms of Interacting Partners?		Elastic Fiber Determination Of Dorsal Identity Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction BMP Binding Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Stem Cell Proliferation NuA4 Histone Acetyltransferase Complex	Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Nucleoplasm Regulation Of Axon Extension RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Importin-alpha Family Protein Binding Positive Regulation Of Cell Development Positive Regulation Of Neurogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neurogenesis
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