RPL29 and IL7R

Number of citations of the paper that reports this interaction (PubMedID 23151878)
60

Data Source:
BioGRID (unspecified method)

		RPL29	IL7R
Description		ribosomal protein L29	interleukin 7 receptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Ribonucleoprotein Complex	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Heparin Binding Cadherin Binding	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Cytoplasmic Translation Translation Embryo Implantation	Regulation Of DNA Recombination Cell Morphogenesis B Cell Homeostasis T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Hemopoiesis T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation T Cell Homeostasis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Lymph Node Development Defense Response To Gram-positive Bacterium Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 31361310 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 34103634 32296059 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Eczema ( 31361310) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 19525953 21833088 24076602) Neutrophil percentage of white cells ( 27863252 32888494) Primary biliary cholangitis ( 26394269 21399635 30643196 23000144 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: BLMH CHD3 GSK3A HMGB1 IL7R RPL6 SYBU	110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		6159	3575
HPRD ID		03495	00893
Ensembl ID		ENSG00000162244	ENSG00000168685
Uniprot IDs		P47914	P16871
PDB IDs		4UG0 4V6X 5AJ0 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	3DI2 3DI3 3UP1 5J11 6P50 6P67 7OPB
Enriched GO Terms of Interacting Partners?		Protein Kinase A Catalytic Subunit Binding Negative Regulation Of UDP-glucose Catabolic Process Energy Reserve Metabolic Process Regulation Of Carbohydrate Catabolic Process Polysaccharide Metabolic Process Regulation Of Glycogen Metabolic Process Glycogen Metabolic Process Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Cysteine-type Aminopeptidase Activity Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Glucose Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance Interleukin-7 Receptor Activity Regulation Of T Cell Mediated Immunity Homocysteine Catabolic Process Response To Glucocorticoid Positive Regulation Of Cell Adhesion Regulation Of Glycogen (starch) Synthase Activity Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Mismatch Repair C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Anterograde Neuronal Dense Core Vesicle Transport Regulation Of Synaptic Activity	RNA Binding Ribonucleoprotein Complex Nucleic Acid Binding RNA Processing MRNA Processing RNA Splicing Spliceosomal Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process MRNA Binding Nucleus Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Positive Regulation Of Gene Expression Cytoplasmic Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Spliceosomal Complex Assembly Regulation Of Translation MRNA Stabilization Regulation Of MRNA Processing U4 SnRNP U1 SnRNP 7-methylguanosine Cap Hypermethylation U12-type Spliceosomal Complex U2-type Prespliceosome Assembly Cytosolic Ribosome Regulation Of RNA Splicing Negative Regulation Of Translation U2 SnRNP Positive Regulation Of Translation Ribosome Positive Regulation Of Cytoplasmic Translation Regulation Of MRNA Stability U2-type Spliceosomal Complex Protein-RNA Complex Assembly Methylosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Stability Negative Regulation Of Gene Expression Regulation Of Gene Expression
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