RPGR and PDE6D

Number of citations of the paper that reports this interaction (PMID 9990021)
21

Data Source:
HPRD (in vitro, two hybrid)

		RPGR	PDE6D
Gene Name		retinitis pigmentosa GTPase regulator	phosphodiesterase 6D, cGMP-specific, rod, delta
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Poly(A) RNA Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding
	Biological Process	Intracellular Protein Transport Visual Perception Intraciliary Transport Cilium Assembly Eye Photoreceptor Cell Development Positive Regulation Of GTPase Activity Response To Stimulus	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium
Drugs
Diseases
GWAS			Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Protein-Protein Interactions		13 interactors: DCTN1 DCTN2 IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE	24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		6103	5147
HPRD ID		02425	04056
Ensembl ID		ENSG00000156313	ENSG00000156973
Uniprot IDs		Q92834	O43924 Q6IB24
PDB IDs		4JHN 4JHP	1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Epidermal Stem Cell Homeostasis Cell Cycle Process G2/M Transition Of Mitotic Cell Cycle Spindle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Spindle Organization Cell Cycle Negative Regulation Of DNA Endoreduplication Establishment Of Vesicle Localization Plus-end-directed Vesicle Transport Along Microtubule Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of DNA Endoreduplication Antigen Processing And Presentation Cytoskeleton Organization Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Establishment Of Organelle Localization Establishment Of Localization In Cell Microtubule-based Transport Inner Ear Receptor Stereocilium Organization Cytoskeleton-dependent Intracellular Transport Organelle Localization Intracellular Transport Sister Chromatid Cohesion Cellular Localization Response To Stress Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Vesicle Transport Along Microtubule Cytoplasmic Microtubule Organization Meiotic Cell Cycle Melanosome Localization Inner Ear Receptor Cell Development Negative Regulation Of DNA Replication Organelle Transport Along Microtubule Cellular Pigmentation Inner Ear Receptor Cell Differentiation Microtubule-based Movement Regulation Of Endoribonuclease Activity	Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process
Tagcloud ?		acuity carriers decade erg examinations eye fields genotypically gtpase hemi identifiable kindred lys756del2aaag minimally oct ophthalmic orf15 perception phenotypically pigmentosa plottable profound puerto retinitis rican spearman teens visual	14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2
Tagcloud (Difference) ?		acuity carriers decade erg examinations eye fields genotypically gtpase hemi identifiable kindred lys756del2aaag minimally oct ophthalmic orf15 perception phenotypically pigmentosa plottable profound puerto retinitis rican spearman teens visual	14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2
Tagcloud (Intersection) ?