RPGR

Name	retinitis pigmentosa GTPase regulator
Structure
Novel Interactors	5 novel interactors: ATP6AP2 NUDT12 SLC9A7 TSPAN7 USP9X
Interactors	15 interactors: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RNF10 RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytoskeleton Cilium Motile Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Photoreceptor Cell Cilium
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Visual Perception Positive Regulation Of Autophagy Protein Ubiquitination Cell Projection Organization Intraciliary Transport Eye Photoreceptor Cell Development Cilium Organization Cilium Assembly Protein Localization To Non-motile Cilium
Diseases	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS	No GWAS studies recorded
Entrez ID	6103
HPRD ID	02425
Ensembl ID	ENSG00000156313
Uniprot IDs	A0A2R8YFT6 Q92834
PDB IDs	4JHN 4JHP 4QAM
GO Terms Enriched among Interactors ?	Cilium Microtubule-based Process Centrosome Microtubule Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Cilium Organization Organelle Assembly Mitotic Spindle Organization Establishment Of Meiotic Sister Chromatid Cohesion Kinesin II Complex Non-motile Cilium Establishment Of Vesicle Localization Microtubule Cytoskeleton Organization Vesicle Localization Cilium Assembly Establishment Of Organelle Localization Meiotic Cohesin Complex Mediator Complex Binding Spindle Microtubule Cytoskeleton Plus-end-directed Vesicle Transport Along Microtubule Ciliary Tip Establishment Of Localization In Cell Condensed Nuclear Chromosome Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Plus-end-directed Organelle Transport Along Microtubule Non-motile Cilium Assembly Organelle Organization Centriole Spindle Organization Establishment Of Sister Chromatid Cohesion Transport Along Microtubule Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Microtubule Anchoring At Centrosome Cytoskeleton-dependent Intracellular Transport Centriole-centriole Cohesion Microtubule Anchoring At Microtubule Organizing Center Microtubule-based Transport Axo-dendritic Transport Organelle Localization Intercellular Bridge Protein Phosphatase Binding Mitotic Sister Chromatid Cohesion Intracellular Transport Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport