RPGR and SLC9A7

Data Source: HiPPIP (Novel)

		RPGR	SLC9A7
Name		retinitis pigmentosa GTPase regulator	solute carrier family 9 member A7
Structure			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytoskeleton Cilium Motile Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Photoreceptor Cell Cilium	Golgi Membrane Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Recycling Endosome Recycling Endosome Membrane
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Visual Perception Positive Regulation Of Autophagy Protein Ubiquitination Cell Projection Organization Intraciliary Transport Eye Photoreceptor Cell Development Cilium Organization Cilium Assembly Protein Localization To Non-motile Cilium	Monoatomic Ion Transport Monoatomic Cation Transport Potassium Ion Transport Sodium Ion Transport Regulation Of PH Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport Regulation Of Golgi Lumen Acidification
Pathways		None	Sodium/Proton exchangers
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	None
GWAS		No GWAS studies recorded	Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) White blood cell count ( 32888494 )
Novel Interactors		5 novel interactors: ATP6AP2 NUDT12 SLC9A7 TSPAN7 USP9X	1 novel interactors: RPGR
Interacting Genes		15 interacting genes: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RNF10 RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE	4 interacting genes: GPR35 SCAMP1 SCAMP2 SCAMP5
Entrez ID		6103	84679
HPRD ID		02425	02297
Ensembl ID		ENSG00000156313	ENSG00000065923
Uniprot IDs		A0A2R8YFT6 Q92834	A0A087WXD1 Q96T83
PDB IDs		4JHN 4JHP 4QAM	Not available
GO Terms Enriched among Interactors		Cilium Microtubule-based Process Centrosome Microtubule Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Cilium Organization Organelle Assembly Mitotic Spindle Organization Establishment Of Meiotic Sister Chromatid Cohesion Kinesin II Complex Non-motile Cilium Establishment Of Vesicle Localization Microtubule Cytoskeleton Organization Vesicle Localization Cilium Assembly Establishment Of Organelle Localization Meiotic Cohesin Complex Mediator Complex Binding Spindle Microtubule Cytoskeleton Plus-end-directed Vesicle Transport Along Microtubule Ciliary Tip Establishment Of Localization In Cell Condensed Nuclear Chromosome Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Plus-end-directed Organelle Transport Along Microtubule Non-motile Cilium Assembly Organelle Organization Centriole Spindle Organization Establishment Of Sister Chromatid Cohesion Transport Along Microtubule Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Microtubule Anchoring At Centrosome Cytoskeleton-dependent Intracellular Transport Centriole-centriole Cohesion Microtubule Anchoring At Microtubule Organizing Center Microtubule-based Transport Axo-dendritic Transport Organelle Localization Intercellular Bridge Protein Phosphatase Binding Mitotic Sister Chromatid Cohesion Intracellular Transport Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport	Trans-Golgi Network Membrane Recycling Endosome Membrane Exocytosis Protein Transport Establishment Of Protein Localization Golgi Apparatus Secretion By Cell Secretion Post-Golgi Vesicle-mediated Transport Intracellular Protein Localization Synaptic Vesicle Membrane Endosome C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Photoreceptor Cell Cilium Golgi Vesicle Transport Protein Localization To Non-motile Cilium Vesicle-mediated Transport Regulation Of Voltage-gated Calcium Channel Activity Zymogen Granule Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Transport Chemokine Receptor Activity Negative Regulation Of Transporter Activity