GNAS and RIC8A

Number of citations of the paper that reports this interaction (PubMedID 12652642)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GNAS	RIC8A
Description		GNAS complex locus	RIC8 guanine nucleotide exchange factor A
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Apical Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Trans-Golgi Network Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Plasma Membrane Cell Cortex Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase Activator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Folding Chaperone
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Renal Water Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Female Pregnancy Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Regulation Of Signal Transduction Regulation Of Skeletal Muscle Contraction Response To Prostaglandin E Negative Regulation Of Multicellular Organism Growth Intracellular Transport Developmental Growth Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Cognition Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Acidic PH Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis	In Utero Embryonic Development Vasculature Development Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Visual Learning Response To Light Stimulus Cell Migration Involved In Gastrulation Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization
Pathways		Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Diseases		Pseudohypoparathyroidism Progressive osseous heteroplasia (POH) Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Colorectal cancer ( 30529582) Creatinine levels ( 29124443) Diastolic blood pressure ( 29403010 30487518 28739976 27618452 21909115) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31152163 31015462 29124443) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 21909115) Hyperuricemia ( 29124443) Mean arterial pressure ( 29403010) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Serum uric acid levels ( 29124443) Sulfasalazine-induced agranulocytosis ( 28762467) Systolic blood pressure ( 27618452 28739976 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 30297969 32499647) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 26785701)	Cataracts ( 34127677) Cataracts (operation) ( 31816047) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Mean corpuscular hemoglobin concentration ( 29403010) Meningioma ( 29762745) Platelet count ( 24026423) Uterine fibroids ( 21460842 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		41 interacting genes: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CFTR CHEK2 CHRM3 CRHR1 CYSLTR2 DRD5 EGFR FZD7 GCGR GLP1R GNGT1 HTR6 LHB LHCGR MSANTD3 MTNR1B NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B RXFP3 SNX13 TBXA2R TSHR TTC1 VIPR1	27 interacting genes: ATP1A4 EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 MID1 NECAB2 NUTM1 OGT PACSIN2 PDE4B RABAC1 SDCBP SH3GLB1 SLC2A13 TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B
Entrez ID		2778	60626
HPRD ID		00761	12373
Ensembl ID		ENSG00000087460	ENSG00000177963
Uniprot IDs		A0A0A0MR13 A0A0S2Z3H8 A0A0S2Z3S5 A0A590UJF0 A0A590UJQ9 A0A590UK28 A0A7I2V5R6 B0AZR9 O95467 P63092 P84996 Q14455 Q5FWY2 Q5JWD1 Q5JWE9 Q5JWF2	Q9NPQ8
PDB IDs		5G53 5UZ7 5VAI 6AU6 6B3J 6E3Y 6E67 6EG8 6GDG 6LI3 6LMK 6LPB 6M1H 6M1I 6NI3 6NIY 6ORV 6P9X 6P9Y 6PB0 6PB1 6UUN 6UUS 6UVA 6VCB 6VN7 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XOX 7AUE 7BB6 7BB7 7BPH 7BW0 7BZ2 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CRH 7CX2 7CX3 7CX4 7CZ5 7D3S 7D7M 7DH5 7DHI 7DHR 7DUQ 7DUR 7DW9 7E14 7E5E 7EPT 7EVM 7EZK 7F0T 7F16 7F1O 7F1Z 7F23 7F24 7F4D 7F4F 7F4H 7F4I 7F53 7F54 7F55 7F58 7JOZ 7JV5 7JVP 7JVQ 7KH0 7KI0 7KI1 7LCI 7LJC 7LJD 7LLL 7LLY 7MBX 7P02 7PIU 7PIV 7RA3 7RBT 7RG9 7RGP 7RMH 7RTB 7S1M 7S3I 7T9I 7T9N 7TMW 7TYF 7TYH 7TYI 7TYL 7TYN 7TYO 7TYW 7TYX 7TYY 7TZF 7UTZ 7V35 7V9L 7V9M 7VAB 7VBH 7VBI 7VUH 7VUI 7VUJ 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7WCM 7WCN 7WQ4 7WU2 7WU3 7WUI 7WUJ 7WUQ 7X2C 7X2D 7X2F 7X8R 7X8S 7XJH 7XJI 7XKD 7XKF 7XOU 7XOV 7XP4 7XP5 7XP6 7XT8 7XT9 7XTB 7XTC 7XTQ 7XW6 7XY6 7XY7 7XZ5 7XZ6 7Y35 7Y36 7Y3G 7YDP 7YP7 7YS6 8E3X 8E3Y 8E3Z 8EL7 8F0J 8F0K 8F2A 8F2B 8F76 8FLQ 8FLR 8FLS 8FLT 8FLU 8FU6 8GD9 8GDA 8GDB 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GW8 8H4I 8HDO 8HDP 8HIX 8HJ0 8HJ1 8HJ2 8HMP 8HMV 8HTI 8I2G 8INR 8IOC 8IOD 8IQ4 8IQ6 8IRV 8IW4 8IW7 8IW9 8IZB 8J9N 8JHB 8JHI 8JIP 8JIQ 8JIR 8JIS 8JIT 8JIU 8JLJ 8JLK 8JLO 8JLQ 8JLR 8JLZ 8JPP 8JR9 8JSO 8K8J 8KGK 8KH4 8KH5 8PM2 8POK 8QJ2 8SMV 8TB0 8TYW 8U26 8U8F 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8UXV 8UXY 8UY0 8UYQ 8VHF 8W88 8W8Q 8W8R 8WC3 8WC4 8WC5 8WC6 8WC7 8WC8 8WG7 8WG8 8WJX 8WW2 8X2K 8X79 8X7A 8XQL 8XQR 8XVE 8XVH 8XVI 8YUT 8YW3 8YW4 8YW5 8YY8 8ZD1 8ZFZ 8ZPS 8ZPT 8ZR5 8ZRK 8ZSJ 8ZSP 8ZSS 8ZSV 9AUC 9BHL 9BHM 9BKK 9EW2 9GYO 9IVG 9J1P 9J31 9JKQ 9JR2 9JR3
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Oxygen-containing Compound Membrane System Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure G-protein Alpha-subunit Binding G Protein-coupled Peptide Receptor Activity Cellular Response To Forskolin Regulation Of System Process Response To Forskolin Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Biological Quality Positive Regulation Of Lyase Activity Regulation Of Blood Circulation Regulation Of Muscle Contraction Positive Regulation Of Cyclase Activity Vascular Process In Circulatory System Regulation Of Signaling Regulation Of Cell Communication Circulatory System Process Positive Regulation Of Blood Pressure Guanyl-nucleotide Exchange Factor Activity Cellular Response To Lipid Cellular Response To Hormone Stimulus Positive Regulation Of Cytosolic Calcium Ion Concentration CAMP Biosynthetic Process Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Muscle System Process Adenylate Cyclase Binding Response To Alcohol Activation Of Adenylate Cyclase Activity Regulation Of Hormone Levels Cellular Response To Peptide Hormone Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Cell-cell Signaling Phosphorus-oxygen Lyase Activity Response To Ketone	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase Regulator Activity GTPase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTP Binding G Protein Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding Cytoplasm Negative Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cell Body Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cellular Component Organization Cytoplasmic Vesicle Regulation Of Cell Communication Centriolar Satellite Regulation Of Protein Localization Regulation Of Signaling Plasma Membrane Regulation Of Transport Negative Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Golgi Apparatus Regulation Of Establishment Of Protein Localization G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endocytosis Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Midbody Identical Protein Binding Regulation Of Macroautophagy Regulation Of Relaxation Of Muscle Negative Regulation Of Receptor Internalization Regulation Of Proteasomal Protein Catabolic Process Extracellular Vesicle Cellular Response To Acidic PH Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Projection G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
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