GNAS and AXIN1

Number of citations of the paper that reports this interaction (PubMedID 16293724)
0

Data Source:
BioGRID (pull down)

		GNAS	AXIN1
Description		GNAS complex locus	axin 1
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Apical Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Trans-Golgi Network Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Cell Periphery Wnt Signalosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase Activator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	P53 Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding Protein Serine/threonine Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Renal Water Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Female Pregnancy Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Regulation Of Signal Transduction Regulation Of Skeletal Muscle Contraction Response To Prostaglandin E Negative Regulation Of Multicellular Organism Growth Intracellular Transport Developmental Growth Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Cognition Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Acidic PH Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis	Protein Polyubiquitination In Utero Embryonic Development Nucleocytoplasmic Transport Apoptotic Process Sensory Perception Of Sound Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Negative Regulation Of Gene Expression Wnt Signaling Pathway Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Post-anal Tail Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of JNK Cascade Axial Mesoderm Development Axial Mesoderm Formation Cell Development Negative Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Head Development Regulation Of Canonical Wnt Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE	1,4-Dithiothreitol
Diseases		Pseudohypoparathyroidism Progressive osseous heteroplasia (POH) Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy	Caudal duplication anomaly Hepatocellular carcinoma
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Colorectal cancer ( 30529582) Creatinine levels ( 29124443) Diastolic blood pressure ( 29403010 30487518 28739976 27618452 21909115) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31152163 31015462 29124443) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 21909115) Hyperuricemia ( 29124443) Mean arterial pressure ( 29403010) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Serum uric acid levels ( 29124443) Sulfasalazine-induced agranulocytosis ( 28762467) Systolic blood pressure ( 27618452 28739976 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 30297969 32499647) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 26785701)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Waist circumference ( 31928498)
Interacting Genes		41 interacting genes: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CFTR CHEK2 CHRM3 CRHR1 CYSLTR2 DRD5 EGFR FZD7 GCGR GLP1R GNGT1 HTR6 LHB LHCGR MSANTD3 MTNR1B NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B RXFP3 SNX13 TBXA2R TSHR TTC1 VIPR1	91 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 FXR1 FXR2 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KAT5 KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RCHY1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TNKS TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSC1 TSGA10 UCHL5 USP10 USP7 UTP14A WSB1 ZBTB26 ZFYVE19
Entrez ID		2778	8312
HPRD ID		00761	04819
Ensembl ID		ENSG00000087460	ENSG00000103126
Uniprot IDs		A0A0A0MR13 A0A0S2Z3H8 A0A0S2Z3S5 A0A590UJF0 A0A590UJQ9 A0A590UK28 A0A7I2V5R6 B0AZR9 O95467 P63092 P84996 Q14455 Q5FWY2 Q5JWD1 Q5JWE9 Q5JWF2	A0A0S2Z4R0 A0A0S2Z4S3 O15169
PDB IDs		5G53 5UZ7 5VAI 6AU6 6B3J 6E3Y 6E67 6EG8 6GDG 6LI3 6LMK 6LPB 6M1H 6M1I 6NI3 6NIY 6ORV 6P9X 6P9Y 6PB0 6PB1 6UUN 6UUS 6UVA 6VCB 6VN7 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XOX 7AUE 7BB6 7BB7 7BPH 7BW0 7BZ2 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CRH 7CX2 7CX3 7CX4 7CZ5 7D3S 7D7M 7DH5 7DHI 7DHR 7DUQ 7DUR 7DW9 7E14 7E5E 7EPT 7EVM 7EZK 7F0T 7F16 7F1O 7F1Z 7F23 7F24 7F4D 7F4F 7F4H 7F4I 7F53 7F54 7F55 7F58 7JOZ 7JV5 7JVP 7JVQ 7KH0 7KI0 7KI1 7LCI 7LJC 7LJD 7LLL 7LLY 7MBX 7P02 7PIU 7PIV 7RA3 7RBT 7RG9 7RGP 7RMH 7RTB 7S1M 7S3I 7T9I 7T9N 7TMW 7TYF 7TYH 7TYI 7TYL 7TYN 7TYO 7TYW 7TYX 7TYY 7TZF 7UTZ 7V35 7V9L 7V9M 7VAB 7VBH 7VBI 7VUH 7VUI 7VUJ 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7WCM 7WCN 7WQ4 7WU2 7WU3 7WUI 7WUJ 7WUQ 7X2C 7X2D 7X2F 7X8R 7X8S 7XJH 7XJI 7XKD 7XKF 7XOU 7XOV 7XP4 7XP5 7XP6 7XT8 7XT9 7XTB 7XTC 7XTQ 7XW6 7XY6 7XY7 7XZ5 7XZ6 7Y35 7Y36 7Y3G 7YDP 7YP7 7YS6 8E3X 8E3Y 8E3Z 8EL7 8F0J 8F0K 8F2A 8F2B 8F76 8FLQ 8FLR 8FLS 8FLT 8FLU 8FU6 8GD9 8GDA 8GDB 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GW8 8H4I 8HDO 8HDP 8HIX 8HJ0 8HJ1 8HJ2 8HMP 8HMV 8HTI 8I2G 8INR 8IOC 8IOD 8IQ4 8IQ6 8IRV 8IW4 8IW7 8IW9 8IZB 8J9N 8JHB 8JHI 8JIP 8JIQ 8JIR 8JIS 8JIT 8JIU 8JLJ 8JLK 8JLO 8JLQ 8JLR 8JLZ 8JPP 8JR9 8JSO 8K8J 8KGK 8KH4 8KH5 8PM2 8POK 8QJ2 8SMV 8TB0 8TYW 8U26 8U8F 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8UXV 8UXY 8UY0 8UYQ 8VHF 8W88 8W8Q 8W8R 8WC3 8WC4 8WC5 8WC6 8WC7 8WC8 8WG7 8WG8 8WJX 8WW2 8X2K 8X79 8X7A 8XQL 8XQR 8XVE 8XVH 8XVI 8YUT 8YW3 8YW4 8YW5 8YY8 8ZD1 8ZFZ 8ZPS 8ZPT 8ZR5 8ZRK 8ZSJ 8ZSP 8ZSS 8ZSV 9AUC 9BHL 9BHM 9BKK 9EW2 9GYO 9IVG 9J1P 9J31 9JKQ 9JR2 9JR3	1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ 6JCK 7SXF 7SXG 7SXH 7SXJ 7Y1P 8RU3 8RU4 8VMG
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Oxygen-containing Compound Membrane System Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure G-protein Alpha-subunit Binding G Protein-coupled Peptide Receptor Activity Cellular Response To Forskolin Regulation Of System Process Response To Forskolin Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Biological Quality Positive Regulation Of Lyase Activity Regulation Of Blood Circulation Regulation Of Muscle Contraction Positive Regulation Of Cyclase Activity Vascular Process In Circulatory System Regulation Of Signaling Regulation Of Cell Communication Circulatory System Process Positive Regulation Of Blood Pressure Guanyl-nucleotide Exchange Factor Activity Cellular Response To Lipid Cellular Response To Hormone Stimulus Positive Regulation Of Cytosolic Calcium Ion Concentration CAMP Biosynthetic Process Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Muscle System Process Adenylate Cyclase Binding Response To Alcohol Activation Of Adenylate Cyclase Activity Regulation Of Hormone Levels Cellular Response To Peptide Hormone Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Cell-cell Signaling Phosphorus-oxygen Lyase Activity Response To Ketone	Wnt Signaling Pathway Cytoplasm Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Wnt Signalosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-catenin Destruction Complex Signal Transduction Beta-catenin Binding PML Body Positive Regulation Of Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?