DHX35 and HSPA13

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DHX35	HSPA13
Description		DEAH-box helicase 35	heat shock protein family A (Hsp70) member 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Binding RNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone
	Biological Process	MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Processing RNA Splicing	Protein Folding Protein Refolding
Pathways		mRNA Splicing - Major Pathway	Regulation of HSF1-mediated heat shock response
Drugs			Copper
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Basal cell carcinoma ( 31174203) Breast cancer and/or colorectal cancer ( 29698419) Chin dimples ( 27182965) Dialysis-related mortality ( 21546767) Femur bone mineral density x serum urate levels interaction ( 34046847) Huntington's disease progression ( 28642124) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Metabolite levels ( 23823483) Nose morphology ( 29921221) Nose size ( 27182965) Serum alkaline phosphatase levels ( 33547301) Telomere length ( 21460395)
Interacting Genes		1 interacting genes: HSPA13	43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT
Entrez ID		60625	6782
HPRD ID		13145	03061
Ensembl ID		ENSG00000101452	ENSG00000155304
Uniprot IDs		Q9H5Z1	A0A140VK72 P48723
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Folding Chaperone ATP-dependent Protein Folding Chaperone Heat Shock Protein Binding Protein Refolding Intracellular Membrane-bounded Organelle Protein Folding	Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process
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