ELAC2 and CTBP2

Number of citations of the paper that reports this interaction (PubMedID 9858600)
28

Data Source:
HPRD (in vivo)

		ELAC2	CTBP2
Description		elaC ribonuclease Z 2	C-terminal binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Nucleoid	Nucleus Transcription Repressor Complex Synapse
	Molecular Function	RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity TRNA-specific Ribonuclease Activity Hydrolase Activity 3'-tRNA Processing Endoribonuclease Activity Metal Ion Binding	Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding NAD Binding DNA-binding Transcription Factor Binding
	Biological Process	TRNA Processing TRNA Decay TRNA 3'-end Processing Mitochondrial TRNA Processing Mitochondrial TRNA 3'-end Processing	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation
Pathways		tRNA processing in the nucleus tRNA processing in the mitochondrion rRNA processing in the mitochondrion tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Squamous cell lung carcinoma ( 28604730)	Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Age-related hearing impairment ( 34108613) Apolipoprotein A1 levels ( 32203549) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Height ( 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) ( 30188897) Menarche (age at onset) ( 25231870) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 18264096) Red blood cell count ( 32888494) Refractive error ( 32231278) Vigorous physical activity ( 29899525) Walking pace ( 33128006)
Interacting Genes		10 interacting genes: ASCC2 CTBP1 CTBP2 CUX1 GOLM1 NDUFA7 RING1 RNF10 SMAD2 SUMO2	96 interacting genes: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 BIRC2 BIRC3 C15orf39 CACNB1 CACNB2 CACNB3 CACNB4 CAPN7 CASP8AP2 CATSPER1 CBX4 CCDC120 CCNH CCR5 CDKN2A CEP68 CSTF2 CTBP1 CTPS2 DCAF6 DMRTB1 DTNB DUSP21 DVL2 EEF1D EGLN3 EIF4G1 ELAC2 ENKD1 EP300 FHL3 FLI1 FUNDC1 GLIS2 H3-4 HEMGN HIC1 HOXA5 HOXB5 HOXC5 IKZF2 KCNIP3 KLF3 KLF8 KYNU LCORL LMO4 MDM2 MECOM NEK6 NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 QARS1 RAI2 RBBP8NL RIMBP3 RNF135 RPL17 RPL7A RPS28 RPS29 RPS4X SDCBP SHISA6 SOX6 STUB1 STX11 TEAD3 TGIF1 TLE5 TRIML2 TSHZ3 UBC UBE2I VRTN XRCC6 ZBP1 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750 ZSCAN4
Entrez ID		60528	1488
HPRD ID		05641	04016
Ensembl ID		ENSG00000006744	ENSG00000175029
Uniprot IDs		A0A0S2Z5M8 Q9BQ52	P56545
PDB IDs		8CBL 8RR1 8RR3 8RR4 8Z0P 8Z1F 8Z1G 9EY0 9EY1 9EY2	2OME 4LCJ 6WKW 8ATI
Enriched GO Terms of Interacting Partners?		Ribosome-associated Ubiquitin-dependent Protein Catabolic Process White Fat Cell Differentiation Viral Genome Replication Regulation Of DNA-templated Transcription NAD Binding DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of RNA Metabolic Process Transcription Corepressor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transcription Repressor Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Homomeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Ubiquitin Protein Ligase Activity Cytosolic Ribosome RQC-trigger Complex GABA-ergic Synapse Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Ligase Complex	Nucleus Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Voltage-gated Calcium Channel Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Voltage-gated Calcium Channel Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process L-type Voltage-gated Calcium Channel Complex Positive Regulation Of Metabolic Process Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator High Voltage-gated Calcium Channel Activity Programmed Cell Death Protein K63-linked Ubiquitination Cell Death Regulation Of Signal Transduction By P53 Class Mediator Monoatomic Ion Channel Complex Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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