ELAC2 and CUX1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ELAC2	CUX1
Gene Name		elaC ribonuclease Z 2	cut-like homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nucleus Cytosol Integral Component Of Golgi Membrane
	Molecular Function	Endonuclease Activity Poly(A) RNA Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding
	Biological Process	Mitochondrial TRNA 3'-trailer Cleavage, Endonucleolytic	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intra-Golgi Vesicle-mediated Transport Multicellular Organismal Development Lung Development Auditory Receptor Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Dendrite Morphogenesis
Pathways			Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS			Response to antidepressants ( 22584459)
Protein-Protein Interactions		8 interactors: ASCC2 CTBP1 CTBP2 CUX1 GOLM1 NDUFA7 RING1 SMAD2	20 interactors: BIN1 CA12 CCNA1 CDC25A CDK1 CDK7 CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 TLE4
Entrez ID		60528	1523
HPRD ID		05641	00295
Ensembl ID		ENSG00000006744	ENSG00000257923
Uniprot IDs		G5E9D5 Q9BQ52	P39880 Q13948 Q3LIA3
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process White Fat Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Viral Genome Replication Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Fat Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Proliferation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Viral Life Cycle Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesoderm Development Primary MiRNA Processing Positive Regulation Of Chromatin Binding Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Transcription From RNA Polymerase II Promoter Positive Regulation Of Activin Receptor Signaling Pathway Lung Development Anterior/posterior Pattern Specification Respiratory Tube Development Negative Regulation Of Histone H4 Acetylation Regulation Of Binding	Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization G1/S Transition Of Mitotic Cell Cycle Chromatin Modification Negative Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cell Division Cell Cycle Process Chromatin Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Viral Process Mitotic Nuclear Division Regulation Of Cell Cycle Cell Cycle Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Histone Modification Mitotic Cell Cycle Process Chromatin Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Protein Kinase Activity Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Regulation Of Nucleic Acid-templated Transcription Protein Localization To Chromosome, Centromeric Region Regulation Of RNA Biosynthetic Process N-terminal Protein Amino Acid Acetylation Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Apoptotic Process Regulation Of Gene Expression Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Cell Death
Tagcloud ?		abundant biogenesis cointroducing constitute created discover discovered endonuclease g2 ligation mature micrornas mirnas northern oligoribonucleotide precise progressively retained rnas sequenced splinted tga throughput tightly trf trfs trna trnas ultra	accumulated activators ancillary base burden cut ectopic excision framework haploinsufficiency homeobox implicated isoform isoforms mechanistic opposite paradoxically progression promotes protection reconcile repressors supports suppression transgenic tumorigenesis tumour whereby yet
Tagcloud (Difference) ?		abundant biogenesis cointroducing constitute created discover discovered endonuclease g2 ligation mature micrornas mirnas northern oligoribonucleotide precise progressively retained rnas sequenced splinted tga throughput tightly trf trfs trna trnas ultra	accumulated activators ancillary base burden cut ectopic excision framework haploinsufficiency homeobox implicated isoform isoforms mechanistic opposite paradoxically progression promotes protection reconcile repressors supports suppression transgenic tumorigenesis tumour whereby yet
Tagcloud (Intersection) ?