RLF and GCH1

Number of citations of the paper that reports this interaction (PMID 16696853)
9

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RLF	GCH1
Gene Name		rearranged L-myc fusion	GTP cyclohydrolase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Coenzyme Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Integration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Metabolic Process Regulation Of Blood Pressure Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Blood Pressure Nitric Oxide Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Protein Heterooligomerization
Pathways			Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases
GWAS			Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		4 interactors: GCH1 PRPF40A RIT1 RIT2	13 interactors: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ
Entrez ID		6018	2643
HPRD ID		01614	02573
Ensembl ID		ENSG00000117000	ENSG00000131979
Uniprot IDs		Q13129	P30793 Q8IZH9
PDB IDs			1FB1
Enriched GO Terms of Interacting Partners?		Olfactory Bulb Axon Guidance Striatal Medium Spiny Neuron Differentiation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Lung Blood Pressure Dihydrobiopterin Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tetrahydrofolate Biosynthetic Process Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Tetrahydrobiopterin Biosynthetic Process T Cell Receptor V(D)J Recombination Post-embryonic Camera-type Eye Development Keratinocyte Development Dopamine Biosynthetic Process Nitric Oxide Biosynthetic Process Striatum Development Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Forebrain Neuron Fate Commitment Catecholamine Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Keratinocyte Proliferation Tetrahydrofolate Metabolic Process Subpallium Development Small GTPase Mediated Signal Transduction Positive Regulation Of Monooxygenase Activity Response To Organic Substance Positive T Cell Selection Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Dopamine Metabolic Process Nitric Oxide Metabolic Process V(D)J Recombination Folic Acid-containing Compound Biosynthetic Process Reactive Nitrogen Species Metabolic Process Vasodilation Pteridine-containing Compound Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Response To Pain T Cell Selection Catecholamine Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Folic Acid-containing Compound Metabolic Process Negative Regulation Of Blood Pressure Epithelial Cell Morphogenesis Pteridine-containing Compound Metabolic Process Regulation Of Cytokinesis Thymus Development Alpha-beta T Cell Differentiation	Intracellular Transport Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Membrane Organization Intracellular Protein Transport Cellular Localization Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Regulated Secretory Pathway Golgi Vesicle Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Negative Regulation Of Fibril Organization Negative Regulation Of GTP Cyclohydrolase I Activity Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling Protein Stabilization Positive Regulation Of Calcium:sodium Antiporter Activity Endomembrane System Organization Positive Regulation Of Potassium Ion Import Regulation Of Fibril Organization Protein Localization Secretion By Cell Golgi Reassembly Positive Regulation Of Sodium Ion Export From Cell Regulation Of Protein Stability Regulation Of Neurotransmitter Levels Regulation Of Metabolic Process Protein Transport Into Plasma Membrane Raft Clathrin Coat Disassembly Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Raft Histamine Secretion By Mast Cell Sodium Ion Export From Cell Establishment Of Golgi Localization Secretion Positive Regulation Of Metabolic Process Sodium Ion Export Golgi Inheritance Regulation Of Catalytic Activity Cellular Potassium Ion Homeostasis Vesicle-mediated Transport Histamine Secretion Transport Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Plasma Membrane Organization Embryonic Process Involved In Female Pregnancy
Tagcloud ?		adjusted adjustment adults advance august died doi ejcn european examination journal lifestyle nlf nmol nutrition obstruction obstructive oh olf online participated prevalent publication restrictive sociodemographic spirometric us worse	allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Difference) ?		adjusted adjustment adults advance august died doi ejcn european examination journal lifestyle nlf nmol nutrition obstruction obstructive oh olf online participated prevalent publication restrictive sociodemographic spirometric us worse	allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Intersection) ?