RGS12 and CXCR2

Number of citations of the paper that reports this interaction (PMID 9651375)
33

Data Source:
HPRD (two hybrid, in vitro)

		RGS12	CXCR2
Gene Name		regulator of G-protein signaling 12	chemokine (C-X-C motif) receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleolus Cytoplasm Plasma Membrane Nuclear Matrix	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mast Cell Granule
	Molecular Function	Receptor Signaling Protein Activity GTPase Activator Activity GTPase Regulator Activity	Signal Transducer Activity Interleukin-8 Receptor Activity Protein Binding C-X-C Chemokine Receptor Activity Interleukin-8 Binding
	Biological Process	Transcription, DNA-templated Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Catalytic Activity	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		15 interactors: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 NPY2R PLCB1 PLCB3 YWHAG	21 interactors: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13
Entrez ID		6002	3579
HPRD ID		03943	00907
Ensembl ID		ENSG00000159788	ENSG00000180871
Uniprot IDs		O14924	P25025 Q53PC4
PDB IDs		2EBZ 2KV8
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Synaptic Transmission Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Regulation Of CAMP Biosynthetic Process Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Regulation Of Phosphorylation Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Synaptic Transmission, Glutamatergic Activation Of MAPKK Activity Regulation Of Cyclase Activity Activation Of Protein Kinase Activity Behavior Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cellular Process G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion Cell Activation G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Cell Cycle Blood Coagulation	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Behavior Inflammatory Response Cytokine-mediated Signaling Pathway Signaling Cell Communication Response To Lipopolysaccharide Receptor Metabolic Process Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Platelet Activation Positive Regulation Of Locomotion Signal Transduction Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Chemotaxis Cellular Response To Stimulus Receptor Internalization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Cytokine Response To External Stimulus Response To Bacterium G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Migration Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility Response To Stress Regulation Of Locomotion Cell Activation Blood Coagulation Cellular Response To Organic Substance Regulation Of Cellular Component Movement Hemostasis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Other Organism Response To Stimulus Regulation Of Cell Proliferation Response To Biotic Stimulus
Tagcloud ?		alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs10 soy sscs supplementation supplements tolerability unsatisfactory	ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Difference) ?		alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs10 soy sscs supplementation supplements tolerability unsatisfactory	ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Intersection) ?