RGS12 and CXCR2

Number of citations: 0 (PubMedID 9651375)
Data Source: HPRD (two hybrid, in vitro)

		RGS12	CXCR2
Name		regulator of G protein signaling 12	C-X-C motif chemokine receptor 2
Structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Cell Projection Synapse	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Apoptotic Process Chemokine-mediated Signaling Pathway
Pathways		G alpha (i) signalling events G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
GWAS		Adult body size ( 32376654 ) Coronary artery disease ( 29212778 ) Creatinine levels ( 29403010 ) Estimated glomerular filtration rate ( 30604766 31015462 ) Glomerular filtration rate ( 29403010 ) Hepatocyte growth factor levels ( 25998175 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Platelet count ( 29403010 ) Serum albumin levels ( 29403010 ) Total cholesterol levels ( 29403010 33339817 ) Tuberculosis ( 29036319 ) Worry too long after an embarrassing experience ( 29500382 )	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Inflammatory bowel disease ( 23128233 28067908 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Smooth-surface caries ( 23470693 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 32888494 )
Interacting Genes		17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG	32 interacting genes: ADRA1A ARLN ARRB1 ATP13A1 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1
Entrez ID		6002	3579
HPRD ID		03943	00907
Ensembl ID		ENSG00000159788	ENSG00000180871
Uniprot IDs		O14924	P25025 Q53PC4
PDB IDs		2EBZ 2KV8	4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO 8XVU 8XWA 8XWF 8XWM 8XWN 8XWS 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX
GO Terms Enriched among Interactors		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Guanyl Nucleotide Binding Signal Transduction G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission GTPase Activity Regulation Of Secretion By Cell Negative Regulation Of Catalytic Activity Glutamate Receptor Signaling Pathway Regulation Of Secretion GTP Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, Glutamatergic Membrane GDP Binding Glutamate Receptor Activity Astrocyte Projection Phospholipase C Activity Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Import Into Cytosol Nucleotide Binding G Protein-coupled Glutamate Receptor Signaling Pathway Intracellular Signal Transduction Schwann Cell Development Regulation Of Catalytic Activity Glutamatergic Synapse G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Ciliary Basal Body Cell-cell Signaling Regulation Of Dopamine Secretion Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Signaling Cell Surface Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Signaling	Chemokine Activity Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Migration Cell Chemotaxis Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Antimicrobial Humoral Response Granulocyte Migration Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Locomotion Leukocyte Chemotaxis G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Leukocyte Migration Inflammatory Response Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Killing Signal Transduction Import Into Cell Signaling Endocytosis Negative Regulation Of Adenylate Cyclase Activity Cell Communication Cell Migration Calcium-mediated Signaling Cytoplasmic Vesicle Membrane GTPase Activity Receptor-mediated Endocytosis Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Molecule Of Bacterial Origin Cell Motility G Protein-coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Response To Other Organism Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Plasma Membrane