RGS12 and NPY2R

Number of citations of the paper that reports this interaction (PubMedID 9651375)
0

Data Source:
HPRD (in vitro)

		RGS12	NPY2R
Description		regulator of G protein signaling 12	neuropeptide Y receptor Y2
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Cell Projection Synapse	Plasma Membrane Cilium Membrane Non-motile Cilium Presynapse Glutamatergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Peptide YY Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Calcium Channel Regulator Activity Protein Binding Signaling Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Behavioral Fear Response Positive Regulation Of Peptide Secretion Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Nitric Oxide Mediated Signal Transduction Locomotory Behavior Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Nervous System Process Positive Regulation Of Dopamine Secretion Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission Negative Regulation Of Secretion Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Synaptic Signaling Via Neuropeptide Negative Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Feeding Behavior
Pathways		G alpha (i) signalling events G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Cysteamine Peptide YY (3-36) Obinepitide
Diseases
GWAS		Adult body size ( 32376654) Coronary artery disease ( 29212778) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31015462) Glomerular filtration rate ( 29403010) Hepatocyte growth factor levels ( 25998175) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Platelet count ( 29403010) Serum albumin levels ( 29403010) Total cholesterol levels ( 29403010 33339817) Tuberculosis ( 29036319) Worry too long after an embarrassing experience ( 29500382)	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Premature menopause in childhood cancer survivors ( 29432556)
Interacting Genes		17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG	4 interacting genes: NPY PYY RGS12 TRARG1
Entrez ID		6002	4887
HPRD ID		03943	01216
Ensembl ID		ENSG00000159788	ENSG00000185149
Uniprot IDs		O14924	P49146
PDB IDs		2EBZ 2KV8	7X9B 7YON 7YOO 8K6N
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Guanyl Nucleotide Binding Signal Transduction G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission GTPase Activity Regulation Of Secretion By Cell Negative Regulation Of Catalytic Activity Glutamate Receptor Signaling Pathway Regulation Of Secretion GTP Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, Glutamatergic Membrane GDP Binding Glutamate Receptor Activity Astrocyte Projection Phospholipase C Activity Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Import Into Cytosol Nucleotide Binding G Protein-coupled Glutamate Receptor Signaling Pathway Intracellular Signal Transduction Schwann Cell Development Regulation Of Catalytic Activity Glutamatergic Synapse G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Ciliary Basal Body Cell-cell Signaling Regulation Of Dopamine Secretion Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Signaling Cell Surface Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Signaling	Neuropeptide Y Receptor Binding Intestinal Epithelial Cell Differentiation Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Feeding Behavior Neuropeptide Signaling Pathway Short-day Photoperiodism Hormone Activity G Protein-coupled Receptor Signaling Pathway Regulation Of Nerve Growth Factor Production Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Glucose Import In Response To Insulin Stimulus Regulation Of Eating Behavior Synaptic Signaling Via Neuropeptide Monocyte Activation Antifungal Humoral Response Adult Feeding Behavior Positive Regulation Of Feeding Behavior Vesicle Fusion To Plasma Membrane Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Epithelial Cell Differentiation Endosome To Plasma Membrane Protein Transport Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food D-glucose Import Regulation Of Dopamine Metabolic Process Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Feeding Behavior GTPase Regulator Activity Photoperiodism D-glucose Transmembrane Transport Positive Regulation Of Behavior Negative Regulation Of Inflammatory Response To Antigenic Stimulus Hexose Transmembrane Transport Regulation Of Response To Nutrient Levels Terminal Bouton Perinuclear Region Of Cytoplasm Positive Regulation Of Nitric Oxide Metabolic Process Calcium Channel Regulator Activity Central Nervous System Neuron Development Negative Regulation Of Blood Pressure Regulation Of Acute Inflammatory Response Carbohydrate Transmembrane Transport
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