RGS12 and GRM2

Number of citations: 0 (PubMedID 9651375)
Data Source: HPRD (in vitro)

		RGS12	GRM2
Name		regulator of G protein signaling 12	glutamate metabotropic receptor 2
Structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Cell Projection Synapse	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug
Pathways		G alpha (i) signalling events G alpha (i) signalling events	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		None	LY2140023
GWAS		Adult body size ( 32376654 ) Coronary artery disease ( 29212778 ) Creatinine levels ( 29403010 ) Estimated glomerular filtration rate ( 30604766 31015462 ) Glomerular filtration rate ( 29403010 ) Hepatocyte growth factor levels ( 25998175 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Platelet count ( 29403010 ) Serum albumin levels ( 29403010 ) Total cholesterol levels ( 29403010 33339817 ) Tuberculosis ( 29036319 ) Worry too long after an embarrassing experience ( 29500382 )	No GWAS studies recorded
Interacting Genes		17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG	31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1
Entrez ID		6002	2912
HPRD ID		03943	04977
Ensembl ID		ENSG00000159788	ENSG00000164082
Uniprot IDs		O14924	H7BXL3 Q14416
PDB IDs		2EBZ 2KV8	4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD
GO Terms Enriched among Interactors		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Guanyl Nucleotide Binding Signal Transduction G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission GTPase Activity Regulation Of Secretion By Cell Negative Regulation Of Catalytic Activity Glutamate Receptor Signaling Pathway Regulation Of Secretion GTP Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Synaptic Transmission, Glutamatergic Membrane GDP Binding Glutamate Receptor Activity Astrocyte Projection Phospholipase C Activity Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Import Into Cytosol Nucleotide Binding G Protein-coupled Glutamate Receptor Signaling Pathway Intracellular Signal Transduction Schwann Cell Development Regulation Of Catalytic Activity Glutamatergic Synapse G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Ciliary Basal Body Cell-cell Signaling Regulation Of Dopamine Secretion Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Signaling Cell Surface Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Signaling	Membrane Plasma Membrane