RGS7 and GNAO1

Number of citations of the paper that reports this interaction (PMID 9572280)
8

Data Source:
HPRD (in vitro)

		RGS7	GNAO1
Gene Name		regulator of G-protein signaling 7	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Dendrite Terminus	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection
	Molecular Function	Signal Transducer Activity GTPase Activator Activity G-protein Beta-subunit Binding	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events	Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		12 interactors: GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ	34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		6000	2775
HPRD ID		03948	00757
Ensembl ID		ENSG00000182901	ENSG00000087258
Uniprot IDs		P49802	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs		2A72 2D9J
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Signal Transduction Negative Regulation Of Transport Regulation Of Intracellular Transport Membrane Organization Platelet Activation Vesicle Fusion Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Localization Organelle Fusion Cellular Response To Stimulus Regulation Of Establishment Of Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Membrane Fusion Positive Regulation Of Organelle Organization Nervous System Development Positive Regulation Of Blood Vessel Endothelial Cell Migration Blood Coagulation Hemostasis Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Response To Stimulus Cytoplasmic Sequestering Of Protein Central Nervous System Development Regulation Of Rhodopsin Mediated Signaling Pathway Detection Of Abiotic Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Metabolic Process Cartilage Development Positive Regulation Of Apoptotic Signaling Pathway Skeletal System Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dopamine Receptor Signaling Pathway Vesicle Organization Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Protein Transport	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell
Tagcloud ?		2a ag490 attenuated cortex corticosterone dependently desensitization frontal hormone hypothalamic increases jak mediating necessary nucleus olanzapine oxytocin paraventricular phospholipase prevented rat reductions regulator release reverse serotonin stat stimulated understand	aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?		2a ag490 attenuated cortex corticosterone dependently desensitization frontal hormone hypothalamic increases jak mediating necessary nucleus olanzapine oxytocin paraventricular phospholipase prevented rat reductions regulator release reverse serotonin stat stimulated understand	aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?