RGS7 and CHRM2

Number of citations: 55 (PubMedID 19182865)
Data Source: BioGRID (pull down)

		RGS7	CHRM2
Name		regulator of G protein signaling 7	cholinergic receptor muscarinic 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Presynaptic Membrane Neuron Projection Dendrite Terminus Postsynaptic Membrane Cell Tip Presynapse Glutamatergic Synapse	Nucleolus Golgi Apparatus Plasma Membrane Cilium Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Ciliary Basal Body Synapse Postsynaptic Membrane Presynapse Cholinergic Synapse
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Arrestin Family Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential	Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		None	Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Cisatracurium Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine Rapacuronium ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Dimetindene Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
GWAS		Chronotype ( 30696823 ) Diastolic blood pressure ( 29208002 ) Longevity (90 years and older) ( 25199915 ) Major depressive disorder ( 27479909 ) Obesity-related traits ( 23251661 ) Post bronchodilator FEV1 ( 26634245 ) Western dietary pattern ( 28644415 )	Copper levels ( 26025379 ) General risk tolerance (MTAG) ( 30643258 ) Heart rate ( 23583979 ) Heart rate response to recovery post exercise ( 29769521 ) Heart rate response to recovery post exercise (10 sec) ( 29497042 ) Heart rate response to recovery post exercise (20 sec) ( 29497042 ) Heart rate response to recovery post exercise (30 sec) ( 29497042 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 ) PR interval ( 32439900 ) Pulse pressure ( 30224653 ) Resting heart rate ( 27798624 29769521 )
Interacting Genes		16 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ	18 interacting genes: GJC2 GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 HERPUD1 MDH1 RGS7 SAG SET SHISA4 SLC52A2 TMEM8B TSPAN33 TSPAN7
Entrez ID		6000	1129
HPRD ID		03948	00328
Ensembl ID		ENSG00000182901	ENSG00000181072
Uniprot IDs		A0A8I5KUA7 A0A8I5KXW5 A0A8I5KZ50 A0A8I5QJU0 B7Z257 P49802	A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1
PDB IDs		2A72 2D9J 7EWP 7EWR 7SHF	3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK 6U1N 7T8X 7T90 7T94 7T96 8J8R 8J97 8JAF
GO Terms Enriched among Interactors		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex G Protein-coupled Acetylcholine Receptor Activity Guanyl Nucleotide Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction G Protein-coupled Serotonin Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Regulation Of Protein Transport Dendrite G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Establishment Of Protein Localization GTPase Activity Regulation Of Transport Regulation Of Insulin Secretion G Protein-coupled Receptor Binding Synapse Regulation Of Peptide Hormone Secretion Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Negative Regulation Of Protein Transport Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Ciliary Basal Body Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Regulation Of Protein Localization Saliva Secretion Trans-synaptic Signaling Synaptic Signaling Regulation Of Secretion GTP Binding Negative Regulation Of Hormone Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality G Protein Activity	G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Phototransduction Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity Protein Phosphatase Inhibitor Activity 4-hydroxybutyrate Receptor Activity Postsynaptic Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Detection Of Light Stimulus Plasma Membrane G Protein-coupled Receptor Catabolic Process Photoreceptor Outer Segment