RFX2 and RFX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		RFX2	RFX6
Description		regulatory factor X2	regulatory factor X6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Acrosome Assembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Spermatid Development Cell Projection Organization Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Cellular Response To Leukemia Inhibitory Factor	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways			Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Mean platelet volume ( 27863252 32888494) Platelet distribution width ( 32888494)	Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Height ( 31562340) Inflammatory bowel disease ( 27569725) Lung cancer ( 28604730) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Prostate cancer ( 31562322 20676098 26443449) Serum total protein levels ( 29403010) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		10 interacting genes: C1orf94 EYA2 FOXJ1 FOXN4 MDFI NFKBID PIAS2 RFX1 RFX4 RFX6	41 interacting genes: AGXT ARNT2 CATSPER1 CCNK CSTF2 CYFIP1 DGCR6 DMRT3 DTX2 DUSP21 ESR2 FHL3 FRS3 HGS KCTD9 KIF1A LGALS4 LMO3 MEMO1 NEDD9 PATZ1 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SAXO4 SNRPB SNRPC SS18L1 STK16 TEKT3 TEKT4 TENT5B TLE5 USP2 VPS37C ZMYND19 ZNF688
Entrez ID		5990	222546
HPRD ID		00824	11490
Ensembl ID		ENSG00000087903	ENSG00000185002
Uniprot IDs		P48378	Q8HWS3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction DNA Binding Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Androgen Receptor Signaling Pathway Pancreatic Epsilon Cell Differentiation Nucleus	Cilium-dependent Cell Motility Axonemal A Tubule Inner Sheath Cilium Movement Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Sperm Motility Flagellated Sperm Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Microtubule-based Movement Protein Localization To Lipid Droplet Protein Binding Nucleus Cilium Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Protein Localization To Vacuole Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Motile Cilium Positive Regulation Of RNA Metabolic Process Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Localization To Lysosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cilium Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Fatty Acid Homeostasis Hepatocyte Apoptotic Process U2-type Prespliceosome Positive Regulation Of Biosynthetic Process Organelle Disassembly Cellular Response To Prostaglandin E Stimulus U1 SnRNP Regulation Of Gene Expression Phosphatidylcholine Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Organelle Assembly Positive Regulation Of Glycolytic Process Regulation Of DNA-templated Transcription
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