RFX2 and RFX6

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RFX2	RFX6
Gene Name		regulatory factor X, 2 (influences HLA class II expression)	regulatory factor X, 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 20676098)
Protein-Protein Interactions		4 interactors: MDFI RFX1 RFX4 RFX6	25 interactors: AES ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 VPS37C
Entrez ID		5990	222546
HPRD ID		00824	11490
Ensembl ID		ENSG00000087903	ENSG00000185002
Uniprot IDs		P48378	Q8HWS3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Dorsal/ventral Pattern Formation Pancreatic D Cell Differentiation Pancreatic Epsilon Cell Differentiation Transcription From RNA Polymerase II Promoter Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Pancreatic A Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Pattern Specification Process Trophoblast Giant Cell Differentiation Transcription, DNA-templated Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Dorsal Spinal Cord Development RNA Biosynthetic Process Type B Pancreatic Cell Differentiation Regulation Of Protein Transport Enteroendocrine Cell Differentiation Cytoplasmic Sequestering Of Protein Regulation Of Establishment Of Protein Localization Positive Regulation Of Cellular Metabolic Process Spinal Cord Dorsal/ventral Patterning Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Smoothened Signaling Pathway Spinal Cord Patterning Activation Of JUN Kinase Activity Regulation Of Protein Localization Cerebellar Cortex Morphogenesis Negative Regulation Of DNA Binding Organ Development Glandular Epithelial Cell Differentiation Regulation Of Signaling Negative Regulation Of Transcription Factor Import Into Nucleus Cerebellum Morphogenesis Hindbrain Morphogenesis RNA Metabolic Process Endocrine Pancreas Development Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Cellular Localization Cerebellar Cortex Development Gene Expression Positive Regulation Of JUN Kinase Activity Negative Regulation Of Signal Transduction	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Energy Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Fatty Acid Homeostasis Transcription From RNA Polymerase II Promoter Epithelial Cell Maturation Nitrogen Compound Metabolic Process Biosynthetic Process Histone-serine Phosphorylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Spliceosomal SnRNP Assembly Histone Phosphorylation Multicellular Organismal Development Sterol Biosynthetic Process Anion Homeostasis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cellular Response To Extracellular Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of TOR Signaling Cellular Component Assembly Type B Pancreatic Cell Maturation Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Necroptotic Process Positive Regulation Of Cellular Metabolic Process Wnt Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Branchiomeric Skeletal Muscle Development Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Tagcloud ?		asymmetry cilia ciliogenesis details foxj1a gpcr gpcrs gpr22 knock kupffer kv lefty1 lefty2 looping lpm lr master mesodermal morpholino organelles orphan patterning pitx2a player protrude randomization southpaw tem vesicle	779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice
Tagcloud (Difference) ?		asymmetry cilia ciliogenesis details foxj1a gpcr gpcrs gpr22 knock kupffer kv lefty1 lefty2 looping lpm lr master mesodermal morpholino organelles orphan patterning pitx2a player protrude randomization southpaw tem vesicle	779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice
Tagcloud (Intersection) ?