RFX2 and RFX4

Number of citations of the paper that reports this interaction (PMID 11682486)
11

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		RFX2	RFX4
Gene Name		regulatory factor X, 2 (influences HLA class II expression)	regulatory factor X, 4 (influences HLA class II expression)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Dorsal Spinal Cord Development Telencephalon Development Cerebellar Cortex Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Midbrain Development Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Processing
Pathways
Drugs
Diseases
GWAS			Cognitive test performance ( 17903297) Heart rate ( 23583979)
Protein-Protein Interactions		4 interactors: MDFI RFX1 RFX4 RFX6	3 interactors: ESR1 RFX2 RFX3
Entrez ID		5990	5992
HPRD ID		00824	04905
Ensembl ID		ENSG00000087903	ENSG00000111783
Uniprot IDs		P48378	Q33E94
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Dorsal/ventral Pattern Formation Pancreatic D Cell Differentiation Pancreatic Epsilon Cell Differentiation Transcription From RNA Polymerase II Promoter Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Pancreatic A Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Pattern Specification Process Trophoblast Giant Cell Differentiation Transcription, DNA-templated Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Dorsal Spinal Cord Development RNA Biosynthetic Process Type B Pancreatic Cell Differentiation Regulation Of Protein Transport Enteroendocrine Cell Differentiation Cytoplasmic Sequestering Of Protein Regulation Of Establishment Of Protein Localization Positive Regulation Of Cellular Metabolic Process Spinal Cord Dorsal/ventral Patterning Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Smoothened Signaling Pathway Spinal Cord Patterning Activation Of JUN Kinase Activity Regulation Of Protein Localization Cerebellar Cortex Morphogenesis Negative Regulation Of DNA Binding Organ Development Glandular Epithelial Cell Differentiation Regulation Of Signaling Negative Regulation Of Transcription Factor Import Into Nucleus Cerebellum Morphogenesis Hindbrain Morphogenesis RNA Metabolic Process Endocrine Pancreas Development Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Cellular Localization Cerebellar Cortex Development Gene Expression Positive Regulation Of JUN Kinase Activity Negative Regulation Of Signal Transduction	Epithelial Cell Development Type B Pancreatic Cell Maturation Prostate Epithelial Cord Elongation Cilium-dependent Cell Motility Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Glandular Epithelial Cell Maturation Transcription, DNA-templated Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy RNA Biosynthetic Process Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Or Flagellum-dependent Cell Motility Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Epithelial Cell Differentiation Regulation Of Type B Pancreatic Cell Development Vagina Development Uterus Development Type B Pancreatic Cell Development Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Prostate Gland Growth Cellular Response To Estradiol Stimulus Epithelial Cell Maturation Branching Involved In Prostate Gland Morphogenesis RNA Metabolic Process Mammary Gland Epithelial Cell Proliferation Epithelial Cilium Movement Type B Pancreatic Cell Differentiation Female Genitalia Development Enteroendocrine Cell Differentiation Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium Gene Expression Cellular Response To Estrogen Stimulus Glandular Epithelial Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Axis Elongation Androgen Metabolic Process Prostate Gland Epithelium Morphogenesis Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Prostate Gland Morphogenesis Positive Regulation Of Nitric Oxide Biosynthetic Process
Tagcloud ?		asymmetry cilia ciliogenesis details foxj1a gpcr gpcrs gpr22 knock kupffer kv lefty1 lefty2 looping lpm lr master mesodermal morpholino organelles orphan patterning pitx2a player protrude randomization southpaw tem vesicle
Tagcloud (Difference) ?		asymmetry cilia ciliogenesis details foxj1a gpcr gpcrs gpr22 knock kupffer kv lefty1 lefty2 looping lpm lr master mesodermal morpholino organelles orphan patterning pitx2a player protrude randomization southpaw tem vesicle
Tagcloud (Intersection) ?